TABLE 1

The fold change and adjusted P values from the SS (+glc +AA) versus SS (−glc +AA) DGE comparison for top genes changing toward or against progression

Gene IDGene productaLogFC (LS vs PF)bAdj. P valuecLogFC (SS+glc vs SS−glc)dAdj. P valuec
Toward progression
    Tb927.6.510GPEET6.220.00E+000.944.70E−14
    Tb927.10.15410gMDH5.230.00E+000.573.00E−27
    Tb927.10.10260EP16.418.53E−3180.861.20E−47
    Tb927.11.6280PPDK4.250.00E+000.31.30E−06
    Tb927.10.2560mMDH3.510.00E+000.31.70E−07
    Tb927.6.520EP3-25.760.00E+000.461.40E−19
    Tb927.7.5940PAD22.149.7596E−1031.21.50E−76
    Tb927.3.4500FHc3.702.89E−3100.282.80E−05
    Tb927.7.210PRODH2.655.36E−3160.579.70E−24
    Tb927.9.5900GDH2.865.3834E−1381.21.30E−82
Against progression
    Tb11.1690VSG−22.120.00E+000.019.20E−01
    Tb927.10.5620ALD−1.511.69E−184−0.413.40E−17
    Tb927.3.3270PFK−2.096.80E−129−0.182.10E−02
    Tb927.10.14140PYK1−2.760.00E+00−0.53.40E−18
    Tb927.10.8230PDI2−2.002.3277E−174−1.12.20E−97
    Tb927.10.2890ENO0.063.42E−01−0.242.10E−05
    Tb927.1.3830PGI−1.498.29E−93−0.292.50E−06
    Tb927.1.700PGKC−3.216.71E−310−0.432.50E−08
    Tb927.10.3990DHH1−0.558.16E−08−0.333.60E−07
    Tb927.10.6880GAP−0.651.01E−25−0.756.50E−47
  • a GPEET, GPEET procyclin; gMDH, glycosomal malate dehydrogenase; EP1, EP1 procyclin; PPDK, pyruvate phosphate dikinase; mMDH, mitochondrial malate dehydrogenase; EP3-2, EP3-2 procyclin; PAD2, protein associated with differentiation 2; FHc, cytosolic fumarate hydratase; PRODH, proline dehydrogenase; GDH, glutamate dehydrogenase; VSG, variant surface glycoprotein; ALD, fructose-bisphosphate aldolase; PFK, ATP-dependent 6-phosphofructokinase; PYK1, pyruvate kinase 1; PDI2, protein disulfide isomerase 2; ENO, enolase; PGI, glucose-6-phosphate isomerase; PGKC, phosphoglycerate kinase C; DHH1, DExD/H-box ATP-dependent RNA helicase.

  • b LogFC (LS vs PF), the log2 fold change value of transcripts from LS incubated in glucose-rich media compared to that from PF very-low-glucose media.

  • c Adjusted P value was calculated using the Benjamini-Hochberg method on P values generated by likelihood ratio.

  • d LogFC (SS+glc vs SS−glc), the log2 fold change value of transcripts from SS incubated in very-low-glucose media compared to that from SS in glucose-rich media.