TABLE 4

Spontaneous resistance frequencies of validated screening hits and rifampin against UAMS-1

DrugSpontaneous resistance frequency (SD)
2× MIC4× MIC
Daunorubicin<1.12 × 10−9 (±1.65 × 10−8)<1.17 × 10−9 (±2.33 × 10−10)
Ketoconazole1.65 × 10−5 (±2.12 × 10−6)5.00 × 10−5 (±1.70 × 10−5)
Rifapentine4.74 × 10−7 (±3.38 × 10−7)1.23 × 10−7 (±3.54 × 10−9)
Sitafloxacin5.68 × 10−6 (±3.44 × 10−6)2.5 × 10−7 (±1.04 × 10−7)
Rifampin4.40 × 10−7 (±2.76 × 10−7)1.71 × 10−7 (±1.56 × 10−9)