TABLE 1 

MICs of D-LAK peptides, rifampin, and capreomycin against M. smegmatis mc2 155 when used alone or in combination, in the presence or absence of tyloxapol

Antimicrobial measured (antimicrobial used in combination)Mean MIC50 ± SE (µM) with:
TyloxapolNo tyloxapol
Rifampin19.9 ± 3.0438.1 ± 5.83
Capreomycin1.72 ± 0.431.35 ± 0.25
D-LAK120-A0.82 ± 0.071.68 ± 0.43
D-LAK120-HP130.63 ± 0.031.80 ± 0.39
Rifampin (D-LAK120-A)9.33 ± 4.3859.8 ± 1.39
Rifampin (D-LAK120-HP13)8.88 ± 1.4414.6 ± 2.91
Capreomycin (D-LAK120-A)0.58 ± 0.240.46 ± 0.18
Capreomycin (D-LAK120-HP13)0.52 ± 0.280.67 ± 0.28
D-LAK120-A (rifampin)0.91 ± 0.051.56 ± 0.17
D-LAK120-A (capreomycin)0.09 ± 0.010.62 ± 0.07
D-LAK120-HP13 (rifampin)0.75 ± 0.220.77 ± 0.08
D-LAK120-HP13 (capreomycin)0.14 ± 0.010.85 ± 0.15