Virus and CVF category | b (SE)^{b} | 95% CI^{c} | P value^{d} |
---|---|---|---|

HIV_{Ba-L} | |||

Native | Ref | ||

Neutralized | 2.59 (0.79) | 1.04, 4.14 | 0.001 |

HIV_{RHPA} | |||

Native | Ref | ||

Neutralized | 6.80 (0.76) | 5.31, 8.28 | <0.001 |

↵a Data represent generalized linear mixed modeling (GLMM) results generalized through specification of a Poisson distribution and log-link function from

*n =*44 data points for HIV_{Ba-L}and*n =*8 data points for HIV_{RHPA}. GLMM was used to apply a random intercept (gamma distribution assumed) for data from each study participant given the repeated HIV-1 infectivity measurement per participant. The (natural) coefficient is the log incidence rate ratio—an exponentiated coefficient yields the percentage of change for a unit (percent) increase for a given factor. The effect represents the difference in log incidence values between study participants’ native and neutralized CVF samples with each participant’s native CVF sample treated as the reference (Ref).↵b Data represent log incidence rate ratio (

*b*) values and associated standard errors (SE). Bootstrapped standard errors (*n =*1,000 replications) were estimated to provide correct inferences in the presence of overdispersion in infectivity in generalized linear modeling.↵c 95% CI, 95% confidence interval.

↵d

*P*value, probability value. Statistical significance was determined at a*P*value of <0.01.