TABLE 5 

Shigella bactericidal responses in subjects immunized with S. flexneri 2a artificial invaplex or orally challenged with S. sonnei 53G in different clinical trials

Vaccine or challenge strain, dose (type of
study; ClinicalTrials registration no.)
Subject
IDa
Day of
study
KIFold increase
over baseline
S. flexneri 2a artificial invaplex, 50 µg
(vaccine trial; NCT02445963)
3001,073
5684,82779
3501,675
56100,55260
3602,194
5678,37836
S. sonnei 53G, 1,500 CFU
(CHIMb; NCT02816346)
134020
146,107305
135020
146,202310
1370381
1424,24664
  • a ID, identification no.

  • b CHIM, controlled human infection model.