TABLE 3 

Comparison of ex vivo cytokine release from blood samples incubated with T27K from subjects with active coccidioidomycosis compared to results from 15 control subjects

CytokineMedian cytokine concn (pg/ml) (range) in samples from:P valuea
Subjects with
coccidioidomycosis
(n = 31)
Immune
controls
(n = 6)
Nonimmune
controls
(n = 9)
GM-CSF204 (0–1,744)44 (5–221)0 (0–59)<0.001
IL-1RA2,461 (0–692,208)4,638 (1,551–36,004)1,977 (0–5,441)0.114
IL-1β309 (0–3,998)36 (4–2,255)4 (0–309)0.011
IFN-γ381 (0–1,854)155 (90–455)0 (0–12)<0.001
IL-2741 (1–2,058)202 (137–310)0 (0–4)<0.001
IL-1344b (0–854)0 (0–11)0 (0–1)<0.001
TNF-α2,584 (1–29,374)543 (23–11,784)8 (0–4,198)0.046
  • a The P values were determined using the nonparametric Kruskal-Wallis test comparing the three groups. The P values in boldface type indicate statistical significance (P ≤ 0.05).

  • b P = 0.0032 comparing subjects to immune controls only.