TABLE 1 

Characteristics and reference isolates of lineages of CC8

Traditional strain
nomenclature
Known isolate(s)
(other names)
Reference(s)Main
SCCmec
type(s)
Main
spa
type(s)
Main
sequence
type
WGS-
based
clade
ST239JKD6008, T0131,
TW20
69–71IIIt037, t431, t030ST239ST239
ST630UnknownVat377a, t4549aST630ST630
ArchaicNewman, COL,
NCTC 10442
11, 15, 72, 73It051ST250CC8a
IberianHPV107, PER34, EMRSA5, E2125,
NRS209 (28243, NR-46003)
11, 15, 21, 54, 55, 74, 75It051ST247CC8a
NCTC 8325, BR-VRSA29, 75II, III, IVabt334ST8, ST1181CC8b
USA500/IberiancNRS385 (95938, NR-46071),
BAA-1763 (GA229)
21, https://www.atcc.org/Products/All/BAA-1763.aspxIVt064ST8CC8c
CMRSA901S-096531, 76VIIIt008ST8CC8d
USA500cBD02-25, CA-224
(NRS645, NR-46174)
7, 21IVt008ST8CC8e
Early Branching
USA300
V2200, HUV0514IVt008ST8CC8e
USA300-NAEFPR3757, TCH1516
(USA300-HOU-MR)
77–79IVat008ST8CC8f
USA300-SAEM121, CA1214IVct008ST8CC8e
  • a t377 is based on this study, and SCCmec type V and t4549 are based on one MRSA isolate (44).

  • b Each SCCmec type is based on one MRSA isolate. Most isolates in this clade are MSSA.

  • c We have made the distinction between USA500 and USA500/Iberian, as recent work (including unpublished data from the CDC and data from Albrecht et al. [4]) has characterized new isolates based on the presence of sea and seb genes (7) and SCCmec type IV. See Materials and Methods for details.