TABLE 1

Identified and validated antifungal compounds from the MMV Malaria Box library with fungicidal activity comparable to or better than that of fluconazolea

TABLE 1
  • a XlogP values are derived from PubChem and describe the lipophilicity of the molecule. The topological polar surface area (tPSA) is a metric for predicting cell penetration, with values of <140 being favorable. The MIC was determined after 72-h drug exposure in liquid culture and continued growth on yeast extract-peptone-dextrose agar plates overnight for recovery of the cultures. Toxicity against human fibroblasts was used to calculate the therapeutic index (TI). ID, identifier; Lipinski, Lipinski's rule of 5 to determine druglikeness of candidate compounds for oral bioavailability in humans; nd, not determined.