TABLE 1

Infant MHC class I and TRIM5α genotypes, number of challenges to infection, percentage of activated CD4+ T cells at the first challenge, and peak and set point VLs

Group
and
animal
SexaNo. of
reads
mapped
MHC class IbTRIM5
genotypec
Susceptibility
scored
No. of
challenges
to infection
Wk 6 %
activated
CD4+ T
cells
VL (no. of RNA
copies/ml)
Mamu-A
haplotype:
Mamu-B
haplotype:
PeakWk 8 p.i.e
1212
Passively
immunized
infants
    808F26,714A008A011B017aB043aTFP/CYP+2Uninfected0.91<15
    983F33,273A001A006B048B012aTFP/TFP0132.93170,000,00032,000
    770F25,501A001A004B048B017aQ/Q+180.3959,000,00026,000
    049F33,176A004A012B002B043aTFP/Q060.988,200,000130,000
    018F25,560A011A019g1B055B013aTFP/TFP−153.64220,000,000200,000
    043F26,592A004A123B001aB043cTFP/TFP−1218.005,800,000210,000
    867F37,442A012A006B001aB001aTFP/TFP−116.17190,000,0002,600,000
Control
infants
    048M32,804A001A002aB048B055Q/CYP0Uninfected1.08<15
    848F32,262A004A019g1B047aB047aQ/Q−184.5715,000,0007,400
    849F33,090A004A004B002B012bTFP/Q063.8321,000,000410,000
    839M31,520A004A003B001aB024aTFP/TFP−151.2950,000,0001,500,000
    992M41,154A004A004B002B043aTFP/Q053.4361,000,000160,000
    020F23,072A004A007B012bB077aTFP/TFP−119.91190,000,0001,000,000
    040F64,939A008A123B024aB043cTFP/TFP−117.565,70065
  • a F, female; M, male.

  • b The Mamu-A1*001, -B*008, and -B*017 alleles (bold) have been associated with a better SIV disease outcome.

  • c The TRIM5α TFP/CypA genotype (bold) confers resistance to SIVsmE660 (46), while the TFP/TFP, Q/Q, and Q/CypA genotypes are associated with increased susceptibility to SIVsmE660 infection.

  • d Protective MHC class I alleles and resistant TRIM5α alleles (Mamu-A1*001, -B*008, -B*017, and TFP/CypA) were assigned a value of 1. Genotypes associated with increased susceptibility or a worse disease outcome received a score of −1. All other alleles were assigned a score of 0. The susceptibility score represents the sum of all scores for an individual animal (e.g., animal 45770 has MHC class I scores of 0, 0, and +1 and a TRIM5α score of −1 for a score of +1).

  • e p.i., postinfection.