TABLE 3

Infant fecal HMO profiles at baseline (postnatal day 6) and postnatal day 29

HMOaMean (SD) HMO concn (mg/ml)Adjusted
P valueb
CON on:EVC001-fed on:
Day 6
(n = 32)
Day 29
(n = 32)
Day 6
(n = 34)
Day 29
(n = 34)
11010.16 (0.25)0.08 (0.13)0.1 (0.09)0 (0.01)0.0664
20016.37 (4.45)5.12 (5.34)5.07 (4.55)0.39 (1.91)0.0056
20200.45 (0.43)0.6 (0.59)0.69 (0.84)0.08 (0.23)0.0688
2-FL1.97 (1.93)2.01 (2)1.57 (1.94)0.03 (0.14)0.0034
30000.68 (1.36)0.53 (1.55)1.3 (2.34)0.01 (0.02)0.4457
31007.88 (6.79)7.56 (11.15)7.35 (8.15)0.47 (1.54)0.0664
31014.25 (2.81)2.16 (1.67)3.11 (2.35)0.1 (0.43)0.0034
LNFP I9.62 (7.41)6.71 (7.08)5.97 (6.43)0.24 (1.27)0.0056
LNFP III,
IV, V
4.97 (2.72)5.71 (3.73)3.75 (3.13)0.12 (0.4)<0.0001
31110.05 (0.05)0.03 (0.04)0.06 (0.07)0.00 (0)0.2198
31200.84 (0.66)1.15 (1.08)0.77 (0.66)0.04 (0.14)0.0001
3′-FL0.99 (0.88)2.27 (2.06)1.23 (1.28)0.05 (0.18)0.0001
42000.7 (0.79)1.23 (1.92)0.76 (1.36)0.39 (0.45)0.2198
42011.24 (1.29)0.96 (1.4)0.89 (0.85)0.09 (0.34)0.0607
42101.96 (1.35)2.61 (2.46)1.66 (1.82)0.3 (0.55)0.0015
42111.34 (0.95)1.55 (1.6)1.13 (1.01)0.13 (0.55)0.0015
42201.01 (0.56)1.53 (1.01)0.79 (0.6)0.11 (0.23)<0.0001
42210.1 (0.09)0.07 (0.11)0.06 (0.06)0.01 (0.02)0.046
42300.21 (0.21)0.4 (0.45)0.18 (0.21)0.02 (0.05)0.0014
43000.28 (0.2)0.25 (0.28)0.18 (0.29)0.82 (0.99)<0.0001
53010.14 (0.12)0.08 (0.13)0.09 (0.08)0.02 (0.03)0.2198
53100.94 (0.58)0.92 (0.95)0.76 (0.87)0.4 (0.44)0.1916
53110.26 (0.19)0.12 (0.12)0.18 (0.18)0.01 (0.03)0.0664
53200.97 (0.61)0.95 (0.89)0.69 (0.65)0.26 (0.25)0.0117
53210.1 (0.08)0.07 (0.06)0.07 (0.07)0 (0.01)0.0047
53300.28 (0.31)0.37 (0.39)0.29 (0.32)0.13 (0.17)0.0838
53310.02 (0.02)0.01 (0.01)0.01 (0.01)0 (0)0.2198
53400.06 (0.05)0.06 (0.06)0.05 (0.06)0.02 (0.03)0.1282
64010.05 (0.06)0.03 (0.05)0.04 (0.06)0.01 (0.01)0.2674
64100.41 (0.34)0.47 (0.61)0.36 (0.51)0.31 (0.36)0.4457
64200.28 (0.25)0.36 (0.39)0.22 (0.25)0.18 (0.18)0.2198
64300.1 (0.09)0.06 (0.07)0.06 (0.07)0.01 (0.03)0.0896
64400.06 (0.05)0.06 (0.05)0.04 (0.04)0.01 (0.02)0.0023
Total48.74 (23.79)46.08 (26.78)39.48 (28.42)4.75 (8.6)<0.0001
  • a 2′-FL, 2′-fucosyllactose; 3′-FL, 3′-fucosyllactose; LNFP, lacto-N-fucosyllpentose. The structural formula for unnamed structures is hexose | hexose-N-acetylglucosamine/galactosamine | fucose | sialic acid.

  • b Day 29 results were compared with a multiple t test with the Holm-Sidak correction.