TABLE 1

FIC index of AmB and caspofungin drug interaction in wild-type C. neoformans

Drug or parameterConcn (µg/ml)
Replicate 1Replicate 2Replicate 3
AmB alone (MICA)0.060.060.06
AmB in combination (MICA′)0.00750.00750.0075
Caspofungin alone (MICC)404040
Caspofungin in combination (MICC′)101010
FIC index = MICA′/MICA + MICC′/MICC0.3750.3750.375
InteractionSynergy (≤0.5)Synergy (≤0.5)Synergy (≤0.5)