TABLE 2

Comparison of resistance genes in Escherichia coli ST131

Antibiotic(s) and antibiotic resistance genefimH allele or sublineageTotal no. of isolates (n = 132)No. of isolates (%) from:P valued
Nepal (n = 54)Japan (n = 12)aOther Asian countries (n = 3)bUSA (n = 29)bEurope (n = 29)b,cAfrica (n = 5)b
Aminoglycoside
aac(3)-IIaTotal2615 (27.8)5 (41.7)03 (10.3)3 (10.3)00.05
H30Rx2515 (27.8)4 (33.3)3 (10.3)3 (10.3)
H30R11 (8.3)
aac(3)-IIdTotal171 (1.9)2 (16.7)1 (33.3)5 (17.2)5 (17.2)3 (60) 0.003
H30Rx31 (1.9)1 (3.4)1 (20)
H30R62 (16.7)1 (33.3)2 (6.9)1 (20)
H2711 (20)
H4172 (6.9)5 (17.2)
aadA1 Total50002 (6.9)3 (10.3)00.213
H30Rx11 (3.4)
H30R32 (6.9)1 (3.4)
H4111 (3.4)
aadA2 Total118 (14.8)002 (6.9)1 (3.4)00.329
H30Rx88 (14.8)
H30R32 (6.9)1 (3.4)
aadA5 Total6831 (57.4)6 (50)021 (72.4)9 (31)1 (20) 0.007
H30Rx5131 (57.4)4 (33.3)13 (44.8)2 (6.9)1 (20)
H30R92 (16.7)6 (20.7)1 (3.4)
H4182 (6.9)4 (13.8)
strA Total4520 (37)2 (16.7)1 (33.3)13 (44.8)6 (20.7)3 (60)0.211
H30Rx2820 (37)1 (8.3)6 (20.7)1 (20)
H30R71 (8.3)1 (33.3)5 (17.2)
H2722 (40)
H4182 (6.9)6 (20.7)
strB Total4920 (37)2 (16.7)1 (33.3)15 (51.7)7 (24.1)4 (80)0.054
H30Rx3020 (37)1 (8.3)8 (27.6)1 (20)
H30R31 (8.3)1 (33.3)1 (20)
H2255 (17.2)
H2722 (40)
H4192 (6.9)7 (24.1)
Aminoglycoside and fluoroquinolone
aac(6')-Ib-crTotal5539 (72.2)6 (50)03 (10.3)7 (24.1)0 <0.001
H30Rx5339 (72.2)5 (41.7)3 (10.3)6 (20.7)
H30R21 (8.3)1 (3.4)
Beta-lactams
bla CTX-M-14 Total200002 (6.9)00.205
H4122 (6.9)
bla CTX-M-15 Total7151 (94.4)8 (66.7)1 (33.3)4 (13.8)6 (20.7)1 (20) <0.001
H30Rx6951 (94.4)7 (58.3)1 (33.3)4 (13.8)5 (17.2)1 (20)
H30R21 (8.3)1 (3.4)
bla CTX-M-27 Total32 (3.7)001 (3.4)000.874
H30Rx22 (3.7)
H30R11 (3.4)
bla CTX-M-55 Total403 (25)1 (33.3)000 <0.001
H30Rx11 (8.3)
H30R32 (16.7)1 (33.3)
bla OXA-1 Total5438 (70.4)7 (58.3)03 (10.3)6 (20.7)0 <0.001
H30Rx5238 (70.4)6 (50)3 (10.3)5 (17.2)
H30R21 (8.3)1 (3.4)
bla TEM-1B Total6120 (37)3 (25)1 (33.3)16 (55.2)16 (55.2)5 (100) 0.036
H30Rx3320 (37)1 (8.3)6 (20.7)4 (13.8)2 (40)
H30R132 (16.7)1 (33.3)8 (27.6)1 (3.4)1 (20)
H2211 (3.4)
H2722 (40)
H41102 (6.9)8 (27.6)
bla TEM-1C Total300003 (10.3)00.05
H2233 (10.3)
bla KPC-3 Total60006 (20.7)00 <0.001
H30Rx66 (20.7)
Macrolide
mphA Total6946 (85.2)5 (41.7)010 (34.5)8 (27.6)0 <0.001
H30Rx5646 (85.2)3 (25)5 (17.2)2 (6.9)
H30R72 (16.7)4 (13.8)1 (3.4)
H4141 (3.4)3 (10.3)
Chloramphenicol
catA1 Total400002 (6.9)2 (40) <0.001
H30Rx11 (20)
H2711 (20)
H4122 (6.9)
catB3 Total5137 (68.5)6 (50)02 (6.9)6 (20.7)0 <0.001
H30Rx4837 (68.5)5 (41.7)1 (3.4)5 (17.2)
H30R31 (8.3)1 (3.4)1 (3.4)
Sulfonamide
sul1 Total8239 (72.2)6 (50)022 (75.9)13 (44.8)2 (40) 0.01
H30Rx6039 (72.2)4 (33.3)13 (44.8)3 (10.3)1 (20)
H30R112 (16.7)7 (24.1)2 (6.9)
H2711 (20)
H4182 (6.9)6 (20.7)
sul2 Total5220 (37)2 (16.7)1 (33.3)18 (62.1)8 (27.6)3 (60) 0.041
H30Rx3220 (37)1 (8.3)9 (31)1 (3.4)1 (20)
H30R91 (8.3)1 (33.3)7 (24.1)
H2722 (40)
H4192 (6.9)7 (24.1)
Trimethoprim
dfrA12 Total88 (14.8)00000 0.031
H30Rx88 (14.8)
dfrA17 Total6731 (57.4)6 (50)020 (69)9 (31)1 (20) 0.014
H30Rx5031 (57.4)4 (33.3)12 (41.3)2 (6.9)1 (20)
H30R92 (16.7)6 (20.7)1 (3.4)
H4162 (6.9)4 (13.8)
dfrA1 Total50001 (3.4)4 (13.8)00.054
H30Rx11 (3.4)
H30R11 (3.4)
H2211 (3.4)
H4122 (6.9)
Tetracycline
tet(A)Total8640 (74.1)8 (66.7)1 (33.3)18 (62.1)15 (51.7)4 (80)0.292
H30Rx6140 (74.1)7 (58.3)11 (37.9)2 (6.9)1 (20)
H30R101 (8.3)1 (33.3)5 (17.2)2 (6.9)1 (20)
H2244 (13.8)
H2722 (40)
H4192 (6.9)7 (24.1)
  • a Includes one publicly available sequence of E. coli ST131.

  • b Publicly available sequence data for E. coli ST131.

  • c Three isolates from Europe were from Lebanon.

  • d The P values are comparing the prevalence of each antibiotic resistance gene among geographical regions. P values in boldface type represent statistically significant results.