TABLE 1

SNPs previously identified in MQ1795 by next-generation deep sequencinga

GeneGene identifierBase no.N16961MQ1795
BaseResidueBaseResidue
hapRVC0583219None (T deletion)NonfunctioningT (insertion)Functioning
hnsVC1130319GGAS
luxOVC1021656CATV
vieAVC1652235CLTF
  • a Single nucleotide polymorphisms (SNPs) of interest found in the hypervirulent MQ1795 strain compared to the El Tor reference strain N16961. MQ1795 has a gain of function in the hapR gene with a mutation that results in the insertion of a thymine. The remaining SNPs (hns, luxO, and vieA) result in neither a gain of function nor a loss of function but rather result in residue changes.