TABLE 3

Unique SNPs in virulence-related genesa of B. pertussis epidemic isolates compared to E476 (Tohama I)

GeneIsolate(s)SNP locationRegion characteristicAmino acid changeProtein expressed? (49)Reference(s)
bapCH374655 A→GString of 2 G’s219 Asp→GlyUnknownThis study
bfrDH5641634 G→AGC-rich region545 Ser→AsnUnknownThis study
bipAH5631070 G→TGC-rich region357 Arg→LeuUnknownThis study
brkAI646640 C→TGC-rich region214 Pro→SerUnknownThis study
bscCH3751677 G→AString of 2 A’sNAbYesThis study; 49
bvgRC39336 C→TString of 3 T’sNAUnknownThis study; 23
bvgSAll epidemic isolates, C3932113 A→GGC-rich region705 Lys→GluYes47, 49, 50, 51, 52
fimDAll epidemic isolates, C393356 T→CGC-rich region119 Phe→SerYes47, 49, 50, 53, 54
ptxBAll epidemic isolates133 G→AGC-rich region45 Gly→SerYes47, 49, 50, 55
ptxCAll epidemic isolates
except H375
681 C→TString of 2 T’sNAYes47, 49, 56
  • a Does not include previously identified SNPs associating with MLST typing loci.

  • b NA, not applicable.