Patient characteristics and their relation to outcome in an OPAa

  • a Patient characteristics of 54 patients with pneumococcal CAP and results from an opsonophagocytic assay (OPA) for corresponding paired acute-phase and convalescent-phase sera. Patients are grouped according to a detectable (>1) or undetectable (1) acute-phase serum OPA titer, as well as the change of the OPA titer from the acute phase to convalescence. Associations of these outcomes with individual patient characteristics were analyzed. Statistically significant differences between groups (P < 0.05) are indicated in bold. CRB-65, confusion of new onset, respiratory rate of 30 breaths/min, systolic blood pressure of <90 mm Hg or diastolic blood pressure of 60 mm Hg or less, age of 65 years or older; SOFA, sequential organ failure assessment; CRP, C-reactive protein.

  • b One or more of any of the following diagnoses: chronic obstructive pulmonary disease (COPD), heart disease, diabetes mellitus, liver disease, renal insufficiency, neoplasm, or immunosuppression.

  • c Fulfilment of the Sepsis-3 definition (33).

  • d Number of days with symptoms of pneumonia before collection of acute-phase serum.