TABLE 2

The 20 most up- and downregulated genes in response to teixobactin in E. faecalis V583 and JH2-2

Gene regulationGene in E. faecalis:Gene nameF/CaFunction
V583JH2-2
UpregulatedEF151813169.5Soluble lytic murein transglycosylase
EF044325238.7Endopeptidase
EF153313297.9Conserved hypothetical protein
EF08025457.8DUF3955 domain-containing protein
EF166514547.6Conjugal transfer protein TraX
EF123110167.6Metallophosphoesterase
EF289624187.2DUF3955 domain-containing protein
EF09326637.1Hypothetical protein
EF29862876.8ABC transporter ATP-binding protein
EF205018176.3Peptide ABC transporter: ATP-binding protein
EF29872866.3RND transporter
EF153213286.2Hypothetical protein
EF00382863proB6.2Glutamate-5-kinase
EF277123476.0TraX family protein
EF125810426.0Hypothetical protein
EF221419185.8VOC family protein
EF11989825.7ABC transporter permease
EF07374845.5Amidase
EF221119155.4YxeA family protein
EF06804225.4Penicillin binding protein 1A
DownregulatedEF04112555−11.6PTS mannitol transporter subunit IICB
EF3139138−10.9PTS sugar transporter subunit IIC
EF04122554−10.2PTS mannitol transporter subunit IIA
EF3141136−9.92-Hydroxyacid dehydrogenase
EF29652466−9.9PTS sugar transporter subunit IIB
EF3142135−9.76-Phosphogluconate dehydrogenase
EF04132553−9.7Mannitol-1-phosphate 5-dehydrogenase
EF321369−9.6PTS mannose transporter subunit IID
EF3140137−9.4Oxidoreductase
EF321171−9.4PTS mannose/fructose/sorbose/N-acetylglucosamine subunit IIB
EF29662467−9.3MltR-like mannitol-operon transcriptional regulator
EF25822168−9.0Chlorohydrolase/aminohydrolase
EF3138139−9.0PTS mannose transporter subunit IID
EF29642465ulaA−8.9PTS ascorbate transporter subunit IIC
EF22231927−8.8ABC transporter family
EF321270−8.7PTS mannose/fructose/sorbose/N-acetylglucosamine subunit IIC
EF33272909−8.7Citrate transporter
EF321072−8.6PTS mannose/fructose/sorbose/N-acetylglucosamine subunit IIA
EF1031742−8.4PTS sugar transporter subunit IIC
EF1207991maeP−8.4l-Malate permease
  • a F/C, log2 fold change.