TABLE 5

IC50s of tazobactam and avibactam against OXA-48, OXA-48:P68A, and OXA-48:P68A,Y211S

Antimicrobial
agent
IC50 (µM) fora:
OXA-48OXA-48:P68AOXA-48:P68A,Y211S
Tazobactam95 ± 94 ± 131 ± 5
Avibactam2.2 ± 0.61.3 ± 0.313 ± 3
  • a IC50s (50% inhibitory concentrations) were determined using nitrocefin as a reporter substrate. Enzymes and inhibitor were incubated together for 5 min. Errors are displayed as 95% confidence intervals.