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Research Article | Molecular Biology and Physiology

Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1

Golnoush Madani, Erwin Lamping, Richard D. Cannon
Aaron P. Mitchell, Editor
Golnoush Madani
aSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand
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Erwin Lamping
aSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand
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  • ORCID record for Erwin Lamping
Richard D. Cannon
aSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand
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Aaron P. Mitchell
University of Georgia
Roles: Editor
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DOI: 10.1128/mSphere.01318-20
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Article Information

DOI 
https://doi.org/10.1128/mSphere.01318-20
PubMed 
33568458

Published By 
American Society for Microbiology Journals
History 
  • Received December 21, 2020
  • Accepted January 13, 2021
  • Published online February 10, 2021.

Copyright & Usage 
Copyright © 2021 Madani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Aaron P. Mitchell, Editor, University of Georgia

Author Information

  1. Golnoush Madania,
  2. Erwin Lampinga and
  3. Richard D. Cannona
  1. aSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand
  • Address correspondence to Erwin Lamping, erwin.lamping{at}otago.ac.nz, or Richard D. Cannon, richard.cannon{at}otago.ac.nz.
  • Golnoush Madani and Erwin Lamping contributed equally to the manuscript. Author order was determined in order of increasing seniority.

  • Citation Madani G, Lamping E, Cannon RD. 2021. Engineering a cysteine-deficient functional Candida albicans Cdr1 molecule reveals a conserved region at the cytosolic apex of ABCG transporters important for correct folding and trafficking of Cdr1. mSphere 6:e01318-20. https://doi.org/10.1128/mSphere.01318-20.

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Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1
Golnoush Madani, Erwin Lamping, Richard D. Cannon
mSphere Feb 2021, 6 (1) e01318-20; DOI: 10.1128/mSphere.01318-20

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Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1
Golnoush Madani, Erwin Lamping, Richard D. Cannon
mSphere Feb 2021, 6 (1) e01318-20; DOI: 10.1128/mSphere.01318-20
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KEYWORDS

PDR transporters
Candida albicans Cdr1
cysteine-less Cdr1
NPAE motif
cysteine cross-linking
multidrug resistance
Saccharomyces cerevisiae hyperexpression

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