Research Article | Clinical Science and Epidemiology

Next-Generation Sequencing Analysis of the Within-Host Genetic Diversity of Influenza A(H1N1)pdm09 Viruses in the Upper and Lower Respiratory Tracts of Patients with Severe Influenza

Ikuyo Takayama, Binh Gia Nguyen, Co Xuan Dao, Thach The Pham, Tuan Quoc Dang, Phuong Thai Truong, Thanh Van Do, Thuy Thi Phuong Pham, Seiichiro Fujisaki, Takato Odagiri, Hideki Hasegawa, Noriko Nakajima
Nicole M. Bouvier, Editor
DOI: 10.1128/mSphere.01043-20

Article Information

DOI 
https://doi.org/10.1128/mSphere.01043-20
PubMed 
33408229
Published By 
American Society for Microbiology Journals
History 
  • Received October 14, 2020
  • Accepted December 16, 2020
  • Published online January 6, 2021.
Copyright & Usage 
Copyright © 2021 Takayama et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Nicole M. Bouvier, Editor, Mount Sinai School of Medicine

Author Information

  1. Ikuyo Takayamaa,
  2. Binh Gia Nguyenb,
  3. Co Xuan Daob,
  4. Thach The Phamb,
  5. Tuan Quoc Dangb,
  6. Phuong Thai Truongb,
  7. Thanh Van Dob,
  8. Thuy Thi Phuong Phamc,
  9. Seiichiro Fujisakia,
  10. Takato Odagiria,
  11. Hideki Hasegawaa and
  12. Noriko Nakajimad
  1. aInfluenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
  2. bBach Mai Hospital, Hanoi, Vietnam
  3. cNCGM-Bach Mai Hospital Medical Collaboration Center, Hanoi, Vietnam
  4. dDepartment of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
  • Address correspondence to Ikuyo Takayama, i-taka{at}nih.go.jp.

  • Ikuyo Takayama and Binh Gia Nguyen contributed equally to this article. Author order was decided based on the specific type of contribution within the collaborating research group.

  • Citation Takayama I, Nguyen BG, Dao CX, Pham TT, Dang TQ, Truong PT, Do TV, Pham TTP, Fujisaki S, Odagiri T, Hasegawa H, Nakajima N. 2021. Next-generation sequencing analysis of the within-host genetic diversity of influenza A(H1N1)pdm09 viruses in the upper and lower respiratory tracts of patients with severe influenza. mSphere 6:e01043-20. https://doi.org/10.1128/mSphere.01043-20.

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KEYWORDS

within-host genetic diversity
H1N1
influenza
D222G/N

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