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Research Article | Clinical Science and Epidemiology

A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease

Fabian Uddén, Jonas Ahl, Nils Littorin, Kristoffer Strålin, Simon Athlin, Kristian Riesbeck
Drusilla L. Burns, Editor
Fabian Uddén
aClinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden
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Jonas Ahl
aClinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden
bInfectious Diseases, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden
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Nils Littorin
aClinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden
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Kristoffer Strålin
cUnit of Infectious Diseases, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
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Simon Athlin
dDepartment of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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  • ORCID record for Simon Athlin
Kristian Riesbeck
aClinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden
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Drusilla L. Burns
U.S. Food and Drug Administration
Roles: Editor
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DOI: 10.1128/mSphere.00925-19
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Article Information

DOI 
https://doi.org/10.1128/mSphere.00925-19
PubMed 
32024704

Published By 
American Society for Microbiology Journals
History 
  • Received December 9, 2019
  • Accepted January 23, 2020
  • Published online February 5, 2020.

Copyright & Usage 
Copyright © 2020 Uddén et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Drusilla L. Burns, Editor, U.S. Food and Drug Administration

Author Information

  1. Fabian Uddéna,
  2. Jonas Ahla,b,
  3. Nils Littorina,
  4. Kristoffer Strålinc,
  5. Simon Athlind and
  6. Kristian Riesbecka
  1. aClinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden
  2. bInfectious Diseases, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden
  3. cUnit of Infectious Diseases, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
  4. dDepartment of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
  • Address correspondence to Kristian Riesbeck, kristian.riesbeck{at}med.lu.se.
  • Citation Uddén F, Ahl J, Littorin N, Strålin K, Athlin S, Riesbeck K. 2020. A nonfunctional opsonic antibody response frequently occurs after pneumococcal pneumonia and is associated with invasive disease. mSphere 5:e00925-19. https://doi.org/10.1128/mSphere.00925-19.

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A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease
Fabian Uddén, Jonas Ahl, Nils Littorin, Kristoffer Strålin, Simon Athlin, Kristian Riesbeck
mSphere Feb 2020, 5 (1) e00925-19; DOI: 10.1128/mSphere.00925-19

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A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease
Fabian Uddén, Jonas Ahl, Nils Littorin, Kristoffer Strålin, Simon Athlin, Kristian Riesbeck
mSphere Feb 2020, 5 (1) e00925-19; DOI: 10.1128/mSphere.00925-19
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KEYWORDS

adaptive immune response
bacteremia
immunoglobulins
opsonization
phagocytosis
pneumonia
Streptococcus pneumoniae

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