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Research Article | Host-Microbe Biology

Toxoplasma Cathepsin Protease B and Aspartyl Protease 1 Are Dispensable for Endolysosomal Protein Digestion

Christian McDonald, David Smith, Manlio Di Cristina, Geetha Kannan, Zhicheng Dou, Vern B. Carruthers
Ira J. Blader, Editor
Christian McDonald
aDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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David Smith
aDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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Manlio Di Cristina
bDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy
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Geetha Kannan
aDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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Zhicheng Dou
cDepartment of Biological Sciences, Clemson University, Clemson, South Carolina, USA
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Vern B. Carruthers
aDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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Ira J. Blader
University at Buffalo
Roles: Editor
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DOI: 10.1128/mSphere.00869-19
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Article Information

DOI 
https://doi.org/10.1128/mSphere.00869-19
PubMed 
32051238

Published By 
American Society for Microbiology Journals
History 
  • Received November 20, 2019
  • Accepted January 24, 2020
  • Published online February 12, 2020.

Copyright & Usage 
Copyright © 2020 McDonald et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Ira J. Blader, Editor, University at Buffalo

Author Information

  1. Christian McDonalda*,
  2. David Smitha*,
  3. Manlio Di Cristinab,
  4. Geetha Kannana,
  5. Zhicheng Douc and
  6. Vern B. Carruthersa
  1. aDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
  2. bDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy
  3. cDepartment of Biological Sciences, Clemson University, Clemson, South Carolina, USA
  • Address correspondence to Zhicheng Dou, zdou{at}clemson.edu, or Vern B. Carruthers, vcarruth{at}umich.edu.
  • ↵* Present address: Christian McDonald, Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA; David Smith, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, UK.

  • Christian McDonald, David Smith, and Zhicheng Dou contributed equally to this article. Their order was determined alphabetically and by seniority.

  • Citation McDonald C, Smith D, Di Cristina M, Kannan G, Dou Z, Carruthers VB. 2020. Toxoplasma cathepsin protease B and aspartyl protease 1 are dispensable for endolysosomal protein digestion. mSphere 5:e00869-19. https://doi.org/10.1128/mSphere.00869-19.

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Toxoplasma Cathepsin Protease B and Aspartyl Protease 1 Are Dispensable for Endolysosomal Protein Digestion
Christian McDonald, David Smith, Manlio Di Cristina, Geetha Kannan, Zhicheng Dou, Vern B. Carruthers
mSphere Feb 2020, 5 (1) e00869-19; DOI: 10.1128/mSphere.00869-19

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Toxoplasma Cathepsin Protease B and Aspartyl Protease 1 Are Dispensable for Endolysosomal Protein Digestion
Christian McDonald, David Smith, Manlio Di Cristina, Geetha Kannan, Zhicheng Dou, Vern B. Carruthers
mSphere Feb 2020, 5 (1) e00869-19; DOI: 10.1128/mSphere.00869-19
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KEYWORDS

Toxoplasma gondii
autophagy
cathepsin
lysosome
proteases

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