Puupehenone, a Marine-Sponge-Derived Sesquiterpene Quinone, Potentiates the Antifungal Drug Caspofungin by Disrupting Hsp90 Activity and the Cell Wall Integrity Pathway

DOI: 10.1128/mSphere.00818-19

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^aNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA
^bDepartment of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA
^cDivision of Medicinal Chemistry, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA
^dNatural Products Utilization Research Unit, U.S. Department of Agriculture, Agricultural Research Service, Oxford, Mississippi, USA
^eVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
^fDivision of Pharmacognosy, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA
^gDivision of Pharmacology, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA

Address correspondence to Ameeta K. Agarwal, aagarwal{at}olemiss.edu.
↵* Present address: Kuldeep K. Roy, Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, India; Xiaomin Shi, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Xuewen Pan, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
Citation Tripathi SK, Feng Q, Liu L, Levin DE, Roy KK, Doerksen RJ, Baerson SR, Shi X, Pan X, Xu W-H, Li X-C, Clark AM, Agarwal AK. 2020. Puupehenone, a marine-sponge-derived sesquiterpene quinone, potentiates the antifungal drug caspofungin by disrupting Hsp90 activity and the cell wall integrity pathway. mSphere 5:e00818-19. https://doi.org/10.1128/mSphere.00818-19.

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