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Minireview | Host-Microbe Biology

Fungal Extracellular Vesicles as Potential Targets for Immune Interventions

Mateus Silveira Freitas, Vânia Luiza Deperon Bonato, Andre Moreira Pessoni, Marcio L. Rodrigues, Arturo Casadevall, Fausto Almeida
Aaron P. Mitchell, Editor
Mateus Silveira Freitas
aDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Vânia Luiza Deperon Bonato
aDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Andre Moreira Pessoni
aDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Marcio L. Rodrigues
bInstituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil
cInstituto de Microbiologia Paulo de Góes (UFRJ), Rio de Janeiro, Brazil
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Arturo Casadevall
dDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
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Fausto Almeida
aDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
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Aaron P. Mitchell
Carnegie Mellon University
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DOI: 10.1128/mSphere.00747-19
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ABSTRACT

The release of extracellular vesicles (EVs) by fungi is a fundamental cellular process. EVs carry several biomolecules, including pigments, proteins, enzymes, lipids, nucleic acids, and carbohydrates, and are involved in physiological and pathological processes. EVs may play a pivotal role in the establishment of fungal infections, as they can interact with the host immune system to elicit multiple outcomes. It has been observed that, depending on the fungal pathogen, EVs can exacerbate or attenuate fungal infections. The study of the interaction between fungal EVs and the host immune system and understanding of the mechanisms that regulate those interactions might be useful for the development of new adjuvants as well as the improvement of protective immune responses against infectious or noninfectious diseases. In this review, we describe the immunomodulatory properties of EVs produced by pathogenic fungi and discuss their potential as adjuvants for prophylactic or therapeutic strategies.

  • Copyright © 2019 Freitas et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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Fungal Extracellular Vesicles as Potential Targets for Immune Interventions
Mateus Silveira Freitas, Vânia Luiza Deperon Bonato, Andre Moreira Pessoni, Marcio L. Rodrigues, Arturo Casadevall, Fausto Almeida
mSphere Nov 2019, 4 (6) e00747-19; DOI: 10.1128/mSphere.00747-19

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Fungal Extracellular Vesicles as Potential Targets for Immune Interventions
Mateus Silveira Freitas, Vânia Luiza Deperon Bonato, Andre Moreira Pessoni, Marcio L. Rodrigues, Arturo Casadevall, Fausto Almeida
mSphere Nov 2019, 4 (6) e00747-19; DOI: 10.1128/mSphere.00747-19
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  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • THE INTERACTION OF FUNGAL EVs WITH THE IMMUNE SYSTEM
    • FUNGAL EVs AS TARGETS FOR IMMUNE INTERVENTIONS
    • ACKNOWLEDGMENTS
    • REFERENCES
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KEYWORDS

drug targets
extracellular vesicles
fungal infections
immune response

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