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Commentary | Therapeutics and Prevention

mSphere of Influence: Uncovering New Ways To Control Multidrug Resistance by Dissecting Essential Cell Processes

Ana L. Flores-Mireles
Ana L. Flores-Mireles
aDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
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DOI: 10.1128/mSphere.00648-19
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ABSTRACT

Ana L. Flores-Mireles works in the fields of microbial pathogenesis and development of new therapeutics. In this mSphere of Influence article, she reflects on how the papers “Bacterial cell wall biogenesis is mediated by SEDS and PBP polymerase families functioning semi-autonomously” by H. Cho et al. (Nat Microbiol 1:16172, 2016, https://doi.org/10.1038/nmicrobiol.2016.172) and “A comprehensive, CRISPR-based functional analysis of essential genes in bacteria” by J. M. Peters et al. (Cell 165:1493–1506, 2016, https://doi.org/10.1016/j.cell.2016.05.003) made an impact on her approach to dissecting essential processes to understand microbial pathogenesis in catheter-associated urinary tract infections and generate an effective treatment with reduced likelihood of developing resistance.

The views expressed in this article do not necessarily reflect the views of the journal or of ASM.

  • Copyright © 2019 Flores-Mireles.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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mSphere of Influence: Uncovering New Ways To Control Multidrug Resistance by Dissecting Essential Cell Processes
Ana L. Flores-Mireles
mSphere Sep 2019, 4 (5) e00648-19; DOI: 10.1128/mSphere.00648-19

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mSphere of Influence: Uncovering New Ways To Control Multidrug Resistance by Dissecting Essential Cell Processes
Ana L. Flores-Mireles
mSphere Sep 2019, 4 (5) e00648-19; DOI: 10.1128/mSphere.00648-19
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KEYWORDS

multidrug resistant
pathogens
antibiotics
CRISPR
essential genes
cell wall
multidrug resistance
pathogen
treatments

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