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Research Article | Therapeutics and Prevention

Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens

Jian Deng, Xiaolei Wang, Bao-Zhong Zhang, Peng Gao, Qiubin Lin, Richard Yi-Tsun Kao, Kenth Gustafsson, Kwok-Yung Yuen, Jian-Dong Huang
Drusilla L. Burns, Editor
Jian Deng
aSchool of Biomedical Sciences, University of Hong Kong, Hong Kong, China
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Xiaolei Wang
aSchool of Biomedical Sciences, University of Hong Kong, Hong Kong, China
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Bao-Zhong Zhang
aSchool of Biomedical Sciences, University of Hong Kong, Hong Kong, China
bShenzhen Institute of Advanced Technologies, Shenzhen, China
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Peng Gao
cDepartment of Microbiology, University of Hong Kong, Hong Kong, China
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Qiubin Lin
aSchool of Biomedical Sciences, University of Hong Kong, Hong Kong, China
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Richard Yi-Tsun Kao
cDepartment of Microbiology, University of Hong Kong, Hong Kong, China
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Kenth Gustafsson
eUCL Institute of Child Health, Molecular Immunology Unit, London, United Kingdom
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Kwok-Yung Yuen
cDepartment of Microbiology, University of Hong Kong, Hong Kong, China
dState Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China
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Jian-Dong Huang
aSchool of Biomedical Sciences, University of Hong Kong, Hong Kong, China
bShenzhen Institute of Advanced Technologies, Shenzhen, China
fHKU-Shenzhen Institute of Research and Innovation, Shenzhen, China
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Drusilla L. Burns
U.S. Food and Drug Administration
Roles: Editor
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DOI: 10.1128/mSphere.00362-19
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Article Information

DOI 
https://doi.org/10.1128/mSphere.00362-19
PubMed 
31484738

Published By 
American Society for Microbiology Journals
History 
  • Received May 20, 2019
  • Accepted July 29, 2019
  • Published online September 4, 2019.

Copyright & Usage 
Copyright © 2019 Deng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Drusilla L. Burns, Editor, U.S. Food and Drug Administration

Author Information

  1. Jian Denga,
  2. Xiaolei Wanga,
  3. Bao-Zhong Zhanga,b,
  4. Peng Gaoc,
  5. Qiubin Lina,
  6. Richard Yi-Tsun Kaoc,
  7. Kenth Gustafssone,
  8. Kwok-Yung Yuenc,d and
  9. Jian-Dong Huanga,b,f
  1. aSchool of Biomedical Sciences, University of Hong Kong, Hong Kong, China
  2. bShenzhen Institute of Advanced Technologies, Shenzhen, China
  3. cDepartment of Microbiology, University of Hong Kong, Hong Kong, China
  4. dState Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China
  5. eUCL Institute of Child Health, Molecular Immunology Unit, London, United Kingdom
  6. fHKU-Shenzhen Institute of Research and Innovation, Shenzhen, China
  • Address correspondence to Kwok-Yung Yuen, kyyuen{at}hkucc.hku.hk, or Jian-Dong Huang, jdhuang{at}hku.hk.
  • J.D., X.W., and B.-Z.Z. contributed equally to this article.

  • Citation Deng J, Wang X, Zhang B-Z, Gao P, Lin Q, Kao RY-T, Gustafsson K, Yuen K-Y, Huang J-D. 2019. Broad and effective protection against Staphylococcus aureus is elicited by a multivalent vaccine formulated with novel antigens. mSphere 4:e00362-19. https://doi.org/10.1128/mSphere.00362-19.

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Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens
Jian Deng, Xiaolei Wang, Bao-Zhong Zhang, Peng Gao, Qiubin Lin, Richard Yi-Tsun Kao, Kenth Gustafsson, Kwok-Yung Yuen, Jian-Dong Huang
mSphere Sep 2019, 4 (5) e00362-19; DOI: 10.1128/mSphere.00362-19

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Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens
Jian Deng, Xiaolei Wang, Bao-Zhong Zhang, Peng Gao, Qiubin Lin, Richard Yi-Tsun Kao, Kenth Gustafsson, Kwok-Yung Yuen, Jian-Dong Huang
mSphere Sep 2019, 4 (5) e00362-19; DOI: 10.1128/mSphere.00362-19
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KEYWORDS

γδ T cell
MRSA
multivalent vaccine

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