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Research Article | Molecular Biology and Physiology

Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance

Rachel L. Darnell, Melanie K. Knottenbelt, Francesca O. Todd Rose, Ian R. Monk, Timothy P. Stinear, Gregory M. Cook
Paul D. Fey, Editor
Rachel L. Darnell
aDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
bMaurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand
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Melanie K. Knottenbelt
aDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
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Francesca O. Todd Rose
aDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
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Ian R. Monk
cDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
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Timothy P. Stinear
cDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
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  • ORCID record for Timothy P. Stinear
Gregory M. Cook
aDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
bMaurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand
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Paul D. Fey
University of Nebraska Medical Center
Roles: Editor
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DOI: 10.1128/mSphere.00228-19
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Article Information

DOI 
https://doi.org/10.1128/mSphere.00228-19
PubMed 
31068434

Published By 
American Society for Microbiology Journals
History 
  • Received March 27, 2019
  • Accepted April 16, 2019
  • Published online May 8, 2019.

Copyright & Usage 
Copyright © 2019 Darnell et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Paul D. Fey, Editor, University of Nebraska Medical Center

Author Information

  1. Rachel L. Darnella,b,
  2. Melanie K. Knottenbelta,
  3. Francesca O. Todd Rosea,
  4. Ian R. Monkc,
  5. Timothy P. Stinearc and
  6. Gregory M. Cooka,b
  1. aDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
  2. bMaurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand
  3. cDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
  • Address correspondence to Gregory M. Cook, greg.cook{at}otago.ac.nz.
  • Citation Darnell RL, Knottenbelt MK, Todd Rose FO, Monk IR, Stinear TP, Cook GM. 2019. Genomewide profiling of the Enterococcus faecalis transcriptional response to teixobactin reveals CroRS as an essential regulator of antimicrobial tolerance. mSphere 4:e00228-19. https://doi.org/10.1128/mSphere.00228-19.

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Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance
Rachel L. Darnell, Melanie K. Knottenbelt, Francesca O. Todd Rose, Ian R. Monk, Timothy P. Stinear, Gregory M. Cook
mSphere May 2019, 4 (3) e00228-19; DOI: 10.1128/mSphere.00228-19

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Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance
Rachel L. Darnell, Melanie K. Knottenbelt, Francesca O. Todd Rose, Ian R. Monk, Timothy P. Stinear, Gregory M. Cook
mSphere May 2019, 4 (3) e00228-19; DOI: 10.1128/mSphere.00228-19
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KEYWORDS

CroRS
Enterococcus
RNA sequencing
teixobactin
antimicrobial resistance
antimicrobial tolerance
mechanisms of resistance

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