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Editor's Pick Research Article | Host-Microbe Biology

Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population

Lisa N. Akhtar, Christopher D. Bowen, Daniel W. Renner, Utsav Pandey, Ashley N. Della Fera, David W. Kimberlin, Mark N. Prichard, Richard J. Whitley, Matthew D. Weitzman, Moriah L. Szpara
Felicia Goodrum, Editor
Lisa N. Akhtar
aDepartment of Pediatrics, Division of Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
eUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
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Christopher D. Bowen
bDepartment of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, The Huck Institutes of the Life Sciences, Pennsylvania State University, State College, Pennsylvania, USA
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Daniel W. Renner
bDepartment of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, The Huck Institutes of the Life Sciences, Pennsylvania State University, State College, Pennsylvania, USA
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Utsav Pandey
bDepartment of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, The Huck Institutes of the Life Sciences, Pennsylvania State University, State College, Pennsylvania, USA
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Ashley N. Della Fera
cDepartment of Pathology and Laboratory Medicine, Division of Protective Immunity and Division of Cancer Pathobiology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
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David W. Kimberlin
dDepartment of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA
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Mark N. Prichard
dDepartment of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA
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Richard J. Whitley
dDepartment of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA
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Matthew D. Weitzman
cDepartment of Pathology and Laboratory Medicine, Division of Protective Immunity and Division of Cancer Pathobiology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
eUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
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Moriah L. Szpara
bDepartment of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, The Huck Institutes of the Life Sciences, Pennsylvania State University, State College, Pennsylvania, USA
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Felicia Goodrum
University of Arizona
Roles: Editor
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DOI: 10.1128/mSphere.00590-18
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Article Information

DOI 
https://doi.org/10.1128/mSphere.00590-18
PubMed 
30814317

Published By 
American Society for Microbiology Journals
History 
  • Received October 30, 2018
  • Accepted February 4, 2019
  • Published online February 27, 2019.

Copyright & Usage 
Copyright © 2019 Akhtar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Felicia Goodrum, Editor, University of Arizona

Author Information

  1. Lisa N. Akhtara,e,
  2. Christopher D. Bowenb,
  3. Daniel W. Rennerb,
  4. Utsav Pandeyb,
  5. Ashley N. Della Ferac,
  6. David W. Kimberlind,
  7. Mark N. Prichardd,
  8. Richard J. Whitleyd,
  9. Matthew D. Weitzmanc,e and
  10. Moriah L. Szparab
  1. aDepartment of Pediatrics, Division of Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
  2. bDepartment of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, The Huck Institutes of the Life Sciences, Pennsylvania State University, State College, Pennsylvania, USA
  3. cDepartment of Pathology and Laboratory Medicine, Division of Protective Immunity and Division of Cancer Pathobiology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
  4. dDepartment of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA
  5. eUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
  • Address correspondence to Matthew D. Weitzman, weitzmanm{at}email.chop.edu, or Moriah L. Szpara, moriah{at}psu.edu.
  • Citation Akhtar LN, Bowen CD, Renner DW, Pandey U, Della Fera AN, Kimberlin DW, Prichard MN, Whitley RJ, Weitzman MD, Szpara ML. 2019. Genotypic and phenotypic diversity of herpes simplex virus 2 within the infected neonatal population. mSphere 4:e00590-18. https://doi.org/10.1128/mSphere.00590-18.

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Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population
Lisa N. Akhtar, Christopher D. Bowen, Daniel W. Renner, Utsav Pandey, Ashley N. Della Fera, David W. Kimberlin, Mark N. Prichard, Richard J. Whitley, Matthew D. Weitzman, Moriah L. Szpara
mSphere Feb 2019, 4 (1) e00590-18; DOI: 10.1128/mSphere.00590-18

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Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population
Lisa N. Akhtar, Christopher D. Bowen, Daniel W. Renner, Utsav Pandey, Ashley N. Della Fera, David W. Kimberlin, Mark N. Prichard, Richard J. Whitley, Matthew D. Weitzman, Moriah L. Szpara
mSphere Feb 2019, 4 (1) e00590-18; DOI: 10.1128/mSphere.00590-18
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KEYWORDS

comparative genomics
herpes simplex virus
human herpesvirus 2
minor variants
neonatal
viral spread

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