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  • Articles
    • Latest Articles
    • COVID-19 Research and News from ASM Journals
    • mSphere of Influence: Commentaries from Early Career Microbiologists
    • Archive
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Therapeutics and Prevention

  • Open Access
    Broad and Effective Protection against <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens
    Research Article | Therapeutics and Prevention
    Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens

    Staphylococcus aureus infections, especially MRSA infections, are becoming a major global health issue and are resulting in mortality rates that are increasing every year. However, an effective vaccine is lacking due to the complexity of the infection process of S. aureus. In this study, we found...

    Jian Deng, Xiaolei Wang, Bao-Zhong Zhang, Peng Gao, Qiubin Lin, Richard Yi-Tsun Kao, Kenth Gustafsson, Kwok-Yung Yuen, Jian-Dong Huang
  • Open Access
    Experimental Mouse Models of Disseminated <span class="named-content genus-species" id="named-content-1">Candida auris</span> Infection
    Research Article | Therapeutics and Prevention
    Experimental Mouse Models of Disseminated Candida auris Infection

    In the last decade, Candida auris has emerged globally as a multidrug‐resistant fungal pathogen. Although C. auris was initially isolated from the external ear canal, it can cause outbreaks of invasive infections with very high mortality and comorbidities. Recent reports highlight the ongoing...

    Hong Xin, Farhan Mohiuddin, Jensen Tran, Abby Adams, Karen Eberle
  • Open Access
    Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <span class="named-content genus-species" id="named-content-1">Candida auris</span>
    Minireview | Therapeutics and Prevention
    Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of Candida auris

    The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community. Over the past decade, our understanding of how this yeast has spread globally, its clinical importance, and how it tolerates and...

    Ryan Kean, Gordon Ramage
  • Open Access
    Treatment of Virulent <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> and HIV Coinfected Macrophages with Gallium Nanoparticles Inhibits Pathogen Growth and Modulates Macrophage Cytokine Production
    Research Article | Therapeutics and Prevention
    Treatment of Virulent Mycobacterium tuberculosis and HIV Coinfected Macrophages with Gallium Nanoparticles Inhibits Pathogen Growth and Modulates Macrophage Cytokine Production

    GaNP interrupts iron-mediated enzymatic reactions, leading to growth inhibition of virulent HIV-M. tuberculosis coinfection in macrophages, and also modulates release of cytokines that may contribute to HIV-TB pathogenesis. Macrophage-targeting GaNP are a promising therapeutic approach to provide sustained antimicrobial activity against HIV-...

    Seoung-ryoung Choi, Bradley E. Britigan, Prabagaran Narayanasamy
  • Open Access
    AIDS Vaccine Research Subcommittee (AVRS) Consultation: Early-Life Immunization Strategies against HIV Acquisition
    Meeting Highlights | Therapeutics and Prevention
    AIDS Vaccine Research Subcommittee (AVRS) Consultation: Early-Life Immunization Strategies against HIV Acquisition

    Young adults represent one of the highest-risk groups for new HIV infections and the only group in which morbidity continues to increase. Therefore, an HIV vaccine to prevent HIV acquisition in adolescence is a top priority. The introduction of any vaccine during adolescence is challenging. This meeting discussed the opportunities and challenges of testing HIV vaccine candidates in the context of the infant immune system given recent...

    Anjali Singh, Sallie Permar, Tobias R. Kollmann, Ofer Levy, Mary Marovich, Kristina De Paris
  • Open Access
    Identification of Mutations in the <em>mrdA</em> Gene Encoding PBP2 That Reduce Carbapenem and Diazabicyclooctane Susceptibility of <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Clinical Isolates with Mutations in <em>ftsI</em> (PBP3) and Which Carry <em>bla</em><sub>NDM-1</sub>
    Observation | Therapeutics and Prevention
    Identification of Mutations in the mrdA Gene Encoding PBP2 That Reduce Carbapenem and Diazabicyclooctane Susceptibility of Escherichia coli Clinical Isolates with Mutations in ftsI (PBP3) and Which Carry blaNDM-1

    Emerging antibacterial resistance is a consequence of the continued use of our current antibacterial therapies, and it is limiting their utility, especially for infections caused by multidrug-resistant isolates. β-Lactams have enjoyed extensive clinical success, but their broad usage is linked to perhaps the most extensive and progressive example of resistance development for any antibacterial scaffold. In Gram-negative pathogens, this...

    Srijan Ranjitkar, Folkert Reck, Xiaobo Ke, Qingming Zhu, Glenn McEnroe, Sara L. Lopez, Charles R. Dean
  • Open Access
    mSphere of Influence: Evolutionary Strategies To Sensitize Drug-Resistant Pathogens
    Commentary | Therapeutics and Prevention
    mSphere of Influence: Evolutionary Strategies To Sensitize Drug-Resistant Pathogens

    Rebecca S. Shapiro studies antimicrobial resistance and genetic interaction networks. In this mSphere of Influence article, she reflects on how the papers “Bacterial evolution of antibiotic hypersensitivity” by Lázár et al. (V. Lázár, G. Pal Singh, R. Spohn, I.

    Rebecca S. Shapiro
  • Open Access
    Questionable Efficacy of Therapeutic Antibodies in the Treatment of Anthrax
    Opinion/Hypothesis | Therapeutics and Prevention
    Questionable Efficacy of Therapeutic Antibodies in the Treatment of Anthrax

    Inhalational anthrax caused by Bacillus anthracis, a spore-forming Gram-positive bacterium, is a highly lethal infection. Antibodies targeting the protective antigen (PA) binding component of the toxins have recently been authorized as an adjunct to antibiotics, although no conclusive evidence demonstrates that anthrax antitoxin therapy has any significant benefit. We...

    Jean-Nicolas Tournier, Clémence Rougeaux, Fabrice V. Biot, Pierre L. Goossens
  • Open Access
    Disarming Pore-Forming Toxins with Biomimetic Nanosponges in Intraocular Infections
    Research Article | Therapeutics and Prevention
    Disarming Pore-Forming Toxins with Biomimetic Nanosponges in Intraocular Infections

    Endophthalmitis is a blinding consequence of bacterial invasion of the interior of the eye. Because of increases in the numbers of ocular surgeries and intraocular injections, the incidence of endophthalmitis is steadily increasing. Staphylococcus aureus, Enterococcus faecalis,...

    Phillip S. Coburn, Frederick C. Miller, Austin L. LaGrow, Craig Land, Huzzatul Mursalin, Erin Livingston, Omar Amayem, Yijie Chen, Weiwei Gao, Liangfang Zhang, Michelle C. Callegan
  • Open Access
    Antibiotics Enhance Prevention and Eradication Efficacy of Cathodic-Voltage-Controlled Electrical Stimulation against Titanium-Associated Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> and <span class="named-content genus-species" id="named-content-2">Pseudomonas aeruginosa</span> Biofilms
    Editor's Pick Research Article | Therapeutics and Prevention
    Antibiotics Enhance Prevention and Eradication Efficacy of Cathodic-Voltage-Controlled Electrical Stimulation against Titanium-Associated Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Biofilms

    Periprosthetic joint infections (PJIs) develop clinically in the presence of antibiotic therapies and are responsible for increased patient morbidity and rising health care costs. Many of these infections involve bacterial biofilm formation on orthopedic hardware, and it has been well established that these biofilms are refractory to most antibiotic treatments. Recent studies have focused on novel methods to prevent and eradicate...

    Mary K. Canty, Lisa A. Hansen, Menachem Tobias, Sandy Spencer, Terry Henry, Nicole R. Luke-Marshall, Anthony A. Campagnari, Mark T. Ehrensberger

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