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  • Articles
    • Latest Articles
    • COVID-19 Research and News from ASM Journals
    • mSphere of Influence: Commentaries from Early Career Microbiologists
    • Archive
  • Topics
    • Applied and Environmental Science
    • Clinical Science and Epidemiology
    • Ecological and Evolutionary Science
    • Host-Microbe Biology
    • Molecular Biology and Physiology
    • Therapeutics and Prevention
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Therapeutics and Prevention

  • Open Access
    Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model
    Research Article | Therapeutics and Prevention
    Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model

    Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic. Smallpox, caused by variola virus (VARV) infection, is highly transmissible, with an estimated 30% mortality.

    Christina L. Hutson, Ashley V. Kondas, Mathew R. Mauldin, Jeffrey B. Doty, Irma M. Grossi, Clint N. Morgan, Sharon Dietz Ostergaard, Christine M. Hughes, Yoshinori Nakazawa, Chantal Kling, Brock E. Martin, James A. Ellison, Darin D. Carroll, Nadia F. Gallardo-Romero, Victoria A. Olson
  • Open Access
    Comprehensive Bioinformatic Assessments of the Variability of <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> Vaccine Candidates
    Research Article | Therapeutics and Prevention
    Comprehensive Bioinformatic Assessments of the Variability of Neisseria gonorrhoeae Vaccine Candidates

    Neisseria gonorrhoeae, the Gram-negative bacterium responsible for the sexually transmitted infection gonorrhea, is categorized as a high-priority pathogen for research and development efforts. N. gonorrhoeae’s “superbug” status, its high morbidity, and the serious health impact associated with...

    Benjamin I. Baarda, Ryszard A. Zielke, Alaina K. Holm, Aleksandra E. Sikora
  • Open Access
    The Fifth International Neonatal and Maternal Immunization Symposium (INMIS 2019): Securing Protection for the Next Generation
    Meeting Highlights | Therapeutics and Prevention
    The Fifth International Neonatal and Maternal Immunization Symposium (INMIS 2019): Securing Protection for the Next Generation

    Despite significant progress in reaching some milestones of the United Nations Sustainable Development Goals, neonatal and early infant morbidity and mortality remain high, and maternal health remains suboptimal in many countries. Novel and improved preventative strategies with the potential to benefit pregnant women and their infants are needed, with maternal and neonatal immunization representing effective approaches.

    ...
    Manish Sadarangani, Tobias Kollmann, Gordean Bjornson, Paul Heath, Ed Clarke, Arnaud Marchant, Ofer Levy, Elke Leuridan, Rolando Ulloa-Gutierrez, Clare L. Cutland, Beate Kampmann, Surasith Chaithongwongwatthana, Ener Dinleyici, Pierre van Damme, Flor M. Munoz
  • Open Access
    Shielding Effect of <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> O-Antigen Polysaccharide on J5-Induced Cross-Reactive Antibodies
    Research Article | Therapeutics and Prevention
    Shielding Effect of Escherichia coli O-Antigen Polysaccharide on J5-Induced Cross-Reactive Antibodies

    Despite intensive research, mastitis remains an important disease in dairy cattle with a significant impact on animal welfare, use of antibiotics, and, in the end, the economy of dairy farms. Although vaccines available so far have shown limited efficacy against coliform mastitis, vaccination is considered one of the measures that could limit the consequences of mastitis.

    Pascal Rainard, Maryline Repérant-Ferter, Christophe Gitton, Pierre Germon
  • Open Access
    Phenotypic and Genotypic Adaptations in <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy
    Research Article | Therapeutics and Prevention
    Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy

    The emergence of multidrug-resistant (MDR) pathogens within biofilms in the cystic fibrosis lung results in increased morbidity. An inhalation therapy derived from alginate, OligoG CF-5/20, is currently in clinical trials for cystic fibrosis patients.

    Juliette L. Oakley, Rebecca Weiser, Lydia C. Powell, Julian Forton, Eshwar Mahenthiralingam, Philip D. Rye, Katja E. Hill, David W. Thomas, Manon F. Pritchard
  • Open Access
    Uncovering the Harms of Treating <span class="named-content genus-species" id="named-content-1">Clostridioides difficile</span> Colonization
    Commentary | Therapeutics and Prevention
    Uncovering the Harms of Treating Clostridioides difficile Colonization

    Patients with toxin-negative Clostridioides difficile-positive diarrhea are often treated with oral vancomycin with the assumption that treatment is more beneficial than harmful. However, this hypothesis has never been formally tested, and recent studies suggest that most such patients recover quickly without treatment and can be colonized rather than infected.

    ...
    Christopher R. Polage, Nicholas A. Turner
  • Open Access
    mSphere of Influence: Turning to Soil for Medicines
    Commentary | Therapeutics and Prevention
    mSphere of Influence: Turning to Soil for Medicines

    Ching-Hsuan Lin works in the field of Candida biology. In this mSphere of Influence article, he reflects on how the papers “Use of ichip for high-throughput in situ cultivation of uncultivable microbial species” by D.

    Ching-Hsuan Lin
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Tolerance and Genomic Response to Photodynamic Inactivation
    Research Article | Therapeutics and Prevention
    Staphylococcus aureus Tolerance and Genomic Response to Photodynamic Inactivation

    Staphylococcus aureus can cause disease at most body sites, with illness ranging from asymptomatic infection to death. The increasing prevalence of antibiotic-resistant strains results in treatment failures and high mortality rates. S. aureus acquires resistance to antibiotics through multiple...

    Sara B. Snell, Ann Lindley Gill, Constantine G. Haidaris, Thomas H. Foster, Timothy M. Baran, Steven R. Gill
  • Open Access
    Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
    Research Article | Therapeutics and Prevention
    Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis

    Currently, the drugs used for toxoplasmosis have severe toxicity to human cells, and the treatment still lacks effective and safer alternatives. The search for novel drug targets is timely.

    Mariana Galvão Ferrarini, Lindice Mitie Nisimura, Richard Marcel Bruno Moreira Girard, Mayke Bezerra Alencar, Mariana Sayuri Ishikawa Fragoso, Carlla Assis Araújo-Silva, Alan de Almeida Veiga, Ana Paula Ressetti Abud, Sheila Cristina Nardelli, Rossiane C. Vommaro, Ariel Mariano Silber, Marie France-Sagot, Andréa Rodrigues Ávila
  • Open Access
    A Novel High-Intensity Focused Ultrasound-Treated Herpes Simplex Virus 2 Vaccine Induces Long-Term Protective Immunity against Lethal Challenge in Mice
    Research Article | Therapeutics and Prevention
    A Novel High-Intensity Focused Ultrasound-Treated Herpes Simplex Virus 2 Vaccine Induces Long-Term Protective Immunity against Lethal Challenge in Mice

    High-intensity focused ultrasound (HIFU) is mainly used in tumor ablation and tumor vaccinology study. It has been shown to induce immune sensitization and enhance tumor responsiveness to other therapies.

    Juhua Xiao, Xin Zhou, Ye Luo, Shuang Wang, Zhili Yang, Yingchun Yi, Hui Xiong

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