Skip to main content
  • ASM Journals
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Latest Articles
    • mSphere of Influence: Commentaries from Early Career Microbiologists
    • Archive
  • Topics
    • Applied and Environmental Science
    • Clinical Science and Epidemiology
    • Ecological and Evolutionary Science
    • Host-Microbe Biology
    • Molecular Biology and Physiology
    • Therapeutics and Prevention
  • For Authors
    • Getting Started
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About mSphere
    • Editor in Chief
    • Board of Editors
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • ASM Journals
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
mSphere
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Latest Articles
    • mSphere of Influence: Commentaries from Early Career Microbiologists
    • Archive
  • Topics
    • Applied and Environmental Science
    • Clinical Science and Epidemiology
    • Ecological and Evolutionary Science
    • Host-Microbe Biology
    • Molecular Biology and Physiology
    • Therapeutics and Prevention
  • For Authors
    • Getting Started
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About mSphere
    • Editor in Chief
    • Board of Editors
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ

Therapeutics and Prevention

  • Open Access
    Alcohol-Based Handrubs and Influenza A
    Letter to the Editor | Therapeutics and Prevention
    Alcohol-Based Handrubs and Influenza A
    John M. Boyce
  • Open Access
    Enrichment of Antigen-Specific Class-Switched B Cells from Individuals Naturally Immunized by Infection with Group A Streptococcus
    Research Article | Therapeutics and Prevention
    Enrichment of Antigen-Specific Class-Switched B Cells from Individuals Naturally Immunized by Infection with Group A Streptococcus

    Bacteria called group A streptococci can cause a variety of skin and soft tissue infections ranging from mild pharyngitis (“strep throat”) to deadly necrotizing fasciitis (sometimes called “flesh-eating” disease). In each case, the development of disease and the degree of tissue damage are mediated by toxins released from the bacteria during infection. Consequently, novel therapies aimed at clearing bacterial toxins are greatly needed....

    Cheri L. Lamb, Emily Price, Kevin P. Field, Christopher Dayton, Eric R. McIndoo, Eva J. Katahira, Dennis L. Stevens, Sarah E. Hobdey
  • Open Access
    Dectin-2-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy
    Research Article | Therapeutics and Prevention
    Dectin-2-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy

    Invasive fungal diseases caused by Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus have mortality rates ranging from 10 to 95%. Individual patient costs may exceed $100,000 in the United States. All...

    Suresh Ambati, Emma C. Ellis, Jianfeng Lin, Xiaorong Lin, Zachary A. Lewis, Richard B. Meagher
  • Open Access
    Maternal Humoral Immune Responses Do Not Predict Postnatal HIV-1 Transmission Risk in Antiretroviral-Treated Mothers from the IMPAACT PROMISE Study
    Research Article | Therapeutics and Prevention
    Maternal Humoral Immune Responses Do Not Predict Postnatal HIV-1 Transmission Risk in Antiretroviral-Treated Mothers from the IMPAACT PROMISE Study

    Each year, >150,000 infants become newly infected with HIV-1 through MTCT despite ART, with up to 42% of infections occurring during breastfeeding. Several factors contribute to continued pediatric infections, including ART nonadherence, the emergence of drug-resistant HIV strains, acute infection during breastfeeding, and poor access to ART in resource-limited areas. A better understanding of the maternal humoral immune responses...

    Eliza D. Hompe, Denise L. Jacobson, Joshua A. Eudailey, Kevin Butler, Whitney Edwards, Justin Pollara, Sean S. Brummel, Genevieve G. Fouda, Lameck Chinula, Melvin Kamanga, Aarti Kinikar, Dhayendre Moodley, Maxensia Owor, Mary Glenn Fowler, Sallie R. Permar
  • Open Access
    Designed Ankyrin Repeat Protein (DARPin) Neutralizers of TcdB from <span class="named-content genus-species" id="named-content-1">Clostridium difficile</span> Ribotype 027
    Research Article | Therapeutics and Prevention
    Designed Ankyrin Repeat Protein (DARPin) Neutralizers of TcdB from Clostridium difficile Ribotype 027

    We report the engineering and characterization of designed ankyrin proteins as potent neutralizers of TcdB toxin secreted by a hypervirulent ribotype 027 strain of Clostridium difficile. We further show that although TcdB toxins from both ribotype 027 and VPI 10461 interact efficiently with TcdB receptors CSPG4 and Pvrl3, TcdB027 lacks significant ability...

    Zeyu Peng, Rudo Simeon, Samuel B. Mitchell, Junjie Zhang, Hanping Feng, Zhilei Chen
  • Open Access
    mSphere of Influence: Uncovering New Ways To Control Multidrug Resistance by Dissecting Essential Cell Processes
    Commentary | Therapeutics and Prevention
    mSphere of Influence: Uncovering New Ways To Control Multidrug Resistance by Dissecting Essential Cell Processes

    Ana L. Flores-Mireles works in the fields of microbial pathogenesis and development of new therapeutics. In this mSphere of Influence article, she reflects on how the papers “Bacterial cell wall biogenesis is mediated by SEDS and PBP polymerase families functioning semi-autonomously” by H.

    Ana L. Flores-Mireles
  • Open Access
    Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
    Perspective | Therapeutics and Prevention
    Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

    Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic. The lack of fundamental understanding of factors controlling clinical efficacy of glycoconjugate vaccines is discussed while key parameters demanding focused and collaborative research are identified.

    Fikri Avci, Francesco Berti, Peter Dull, John Hennessey, Viliam Pavliak, A. Krishna Prasad, Willie Vann, Michael Wacker, Olivier Marcq
  • Open Access
    Identification of 4-Amino-Thieno[2,3-<em>d</em>]Pyrimidines as QcrB Inhibitors in <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span>
    Research Article | Therapeutics and Prevention
    Identification of 4-Amino-Thieno[2,3-d]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis

    The global tuberculosis (TB) epidemic has been exacerbated by the rise in drug-resistant TB cases worldwide. To tackle this crisis, it is necessary to identify new vulnerable drug targets in Mycobacterium tuberculosis, the causative agent of TB, and develop compounds that can inhibit the bacterium through novel mechanisms of action. The QcrB subunit of the electron...

    Gregory A. Harrison, Anne E. Mayer Bridwell, Megh Singh, Keshav Jayaraman, Leslie A. Weiss, Rachel L. Kinsella, Janessa S. Aneke, Kelly Flentie, Miranda E. Schene, Margaret Gaggioli, Samantha D. Solomon, Scott A. Wildman, Marvin J. Meyers, Christina L. Stallings
  • Open Access
    Experimental Mouse Models of Disseminated <span class="named-content genus-species" id="named-content-1">Candida auris</span> Infection
    Research Article | Therapeutics and Prevention
    Experimental Mouse Models of Disseminated Candida auris Infection

    In the last decade, Candida auris has emerged globally as a multidrug‐resistant fungal pathogen. Although C. auris was initially isolated from the external ear canal, it can cause outbreaks of invasive infections with very high mortality and comorbidities. Recent reports highlight the ongoing...

    Hong Xin, Farhan Mohiuddin, Jensen Tran, Abby Adams, Karen Eberle
  • Open Access
    Broad and Effective Protection against <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens
    Research Article | Therapeutics and Prevention
    Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens

    Staphylococcus aureus infections, especially MRSA infections, are becoming a major global health issue and are resulting in mortality rates that are increasing every year. However, an effective vaccine is lacking due to the complexity of the infection process of S. aureus. In this study, we found...

    Jian Deng, Xiaolei Wang, Bao-Zhong Zhang, Peng Gao, Qiubin Lin, Richard Yi-Tsun Kao, Kenth Gustafsson, Kwok-Yung Yuen, Jian-Dong Huang

Pages

  • Next
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • …
  • 12
Back to top

About

  • About mSphere
  • Board of Editors
  • Policies
  • For Reviewers
  • For the Media
  • Embargo Policy
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Author Warranty
  • Types of Articles
  • Getting Started
  • Ethics
  • Contact Us

Follow #mSphereJ

@ASMicrobiology

       

 

Website feedback

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

Copyright © 2019 American Society for Microbiology | Privacy Policy | Website feedback

Online ISSN: 2379-5042