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Molecular Biology and Physiology

  • Open Access
    The Major Chromosome Condensation Factors Smc, HBsu, and Gyrase in <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Operate via Strikingly Different Patterns of Motion
    Research Article | Molecular Biology and Physiology
    The Major Chromosome Condensation Factors Smc, HBsu, and Gyrase in Bacillus subtilis Operate via Strikingly Different Patterns of Motion

    All types of cells need to compact their chromosomes containing their genomic information several-thousand-fold in order to fit into the cell. In eukaryotes, histones achieve a major degree of compaction and bind very tightly to DNA such that they need to be actively removed to allow access of polymerases to the DNA. Bacteria have evolved a basic, highly dynamic system of DNA compaction, accommodating rapid adaptability to changes in...

    Sonja Schibany, Rebecca Hinrichs, Rogelio Hernández-Tamayo, Peter L. Graumann
  • Open Access
    Production of Diverse Beauveriolide Analogs in Closely Related Fungi: a Rare Case of Fungal Chemodiversity
    Research Article | Molecular Biology and Physiology
    Production of Diverse Beauveriolide Analogs in Closely Related Fungi: a Rare Case of Fungal Chemodiversity

    Fungal chemotaxonomy is an approach to classify fungi based on the fungal production profile of metabolites, especially the secondary metabolites. We found an atypical example that could question the reliability of fungal chemical classifications in this study, i.e., the more closely related entomopathogenic species Beauveria bassiana and...

    Ying Yin, Bo Chen, Shuangxiu Song, Bing Li, Xiuqing Yang, Chengshu Wang
  • Open Access
    Use of CRISPR-Cas9 To Target Homologous Recombination Limits Transformation-Induced Genomic Changes in <span class="named-content genus-species" id="named-content-1">Candida albicans</span>
    Editor's Pick Research Article | Molecular Biology and Physiology
    Use of CRISPR-Cas9 To Target Homologous Recombination Limits Transformation-Induced Genomic Changes in Candida albicans

    Genome editing is essential to nearly all research studies aimed at gaining insight into the molecular mechanisms underlying various biological processes, including those in the opportunistic pathogen Candida albicans. The adaptation of the CRISPR-Cas9 system greatly facilitates genome engineering in many organisms. However, our understanding of the effects of CRISPR-...

    Timea Marton, Corinne Maufrais, Christophe d’Enfert, Melanie Legrand
  • Open Access
    Antibiotic Resistance in <span class="named-content genus-species" id="named-content-1">Vibrio cholerae</span>: Mechanistic Insights from IncC Plasmid-Mediated Dissemination of a Novel Family of Genomic Islands Inserted at <em>trmE</em>
    Research Article | Molecular Biology and Physiology
    Antibiotic Resistance in Vibrio cholerae: Mechanistic Insights from IncC Plasmid-Mediated Dissemination of a Novel Family of Genomic Islands Inserted at trmE

    The increasing association of the etiological agent of cholera, Vibrio cholerae serogroup O1 and O139, with multiple antibiotic resistance threatens to deprive health practitioners of this effective tool. Drug resistance in cholera results mainly from acquisition of mobile genetic elements. Genomic islands conferring multidrug resistance and mobilizable by IncC...

    Nicolas Rivard, Rita R. Colwell, Vincent Burrus
  • Open Access
    Generation of Viable <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Mutants Lacking the “Essential” Protein Kinase Snf1 by Inducible Gene Deletion
    Editor's Pick Research Article | Molecular Biology and Physiology
    Generation of Viable Candida albicans Mutants Lacking the “Essential” Protein Kinase Snf1 by Inducible Gene Deletion

    Essential genes are those that are indispensable for the viability and growth of an organism. Previous studies indicated that the protein kinase Snf1, a central regulator of metabolic adaptation, is essential in the pathogenic yeast Candida albicans, because no homozygous snf1 deletion mutants of ...

    Austin Mottola, Sonja Schwanfelder, Joachim Morschhäuser
  • Open Access
    The Parameter-Fitness Landscape of <em>lexA</em> Autoregulation in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Research Article | Molecular Biology and Physiology
    The Parameter-Fitness Landscape of lexA Autoregulation in Escherichia coli

    Feedback mechanisms are critical to control physiological responses. In gene regulation, one important example, termed negative autoregulation (NAR), occurs when a transcription factor (TF) inhibits its own production. NAR is common across the tree of life, enabling rapid homeostatic control of gene expression. NAR behavior can be described in accordance with its core biochemical parameters, but how constrained these parameters are by...

    Beverley C. Kozuch, Marla G. Shaffer, Matthew J. Culyba
  • Open Access
    Characterization of Extracellular Vesicles Produced by <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span> Protoplasts
    Research Article | Molecular Biology and Physiology
    Characterization of Extracellular Vesicles Produced by Aspergillus fumigatus Protoplasts

    Fungal cells use extracellular vesicles (EVs) to export biologically active molecules to the extracellular space. In this study, we used protoplasts of Aspergillus fumigatus, a major fungal pathogen, as a model to evaluate the role of EV production in cell wall biogenesis. Our results demonstrated that wall-less...

    Juliana Rizzo, Thibault Chaze, Kildare Miranda, Robert W. Roberson, Olivier Gorgette, Leonardo Nimrichter, Mariette Matondo, Jean-Paul Latgé, Anne Beauvais, Marcio L. Rodrigues
  • Open Access
    Redesigned TetR-Aptamer System To Control Gene Expression in <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span>
    Research Article | Molecular Biology and Physiology
    Redesigned TetR-Aptamer System To Control Gene Expression in Plasmodium falciparum

    Malaria elimination efforts have been repeatedly hindered by the evolution and spread of multidrug-resistant strains of Plasmodium falciparum. The absence of a commercially available vaccine emphasizes the need for a better understanding of Plasmodium biology in order to further translational research. This has been partly facilitated by targeted gene...

    Krithika Rajaram, Hans B. Liu, Sean T. Prigge
  • Open Access
    Integrative Analysis of Proteome and Transcriptome Dynamics during <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Spore Revival
    Research Article | Molecular Biology and Physiology
    Integrative Analysis of Proteome and Transcriptome Dynamics during Bacillus subtilis Spore Revival

    This study demonstrated the progress of macromolecular synthesis during Bacillus subtilis spore germination and outgrowth. The transcriptome analysis has additionally allowed us to trace gene expression during this transformation process. For the first time, the basic survival kit for spore-based life has been identified. In addition, in this analysis based on...

    Bhagyashree Swarge, Wishwas Abhyankar, Martijs Jonker, Huub Hoefsloot, Gertjan Kramer, Peter Setlow, Stanley Brul, Leo J. de Koning
  • Open Access
    Investigating Synthesis of the MalS Malic Enzyme during <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Spore Germination and Outgrowth and the Influence of Spore Maturation and Sporulation Conditions
    Research Article | Molecular Biology and Physiology
    Investigating Synthesis of the MalS Malic Enzyme during Bacillus subtilis Spore Germination and Outgrowth and the Influence of Spore Maturation and Sporulation Conditions

    The spores formed by Bacillus subtilis remain in a quiescent state for extended periods due to their dormancy and resistance features. Dormancy is linked to a very low level of core water content and a phase-bright state of spores. The present report, focusing on proteins MalS and PdhD (pyruvate dehydrogenase subunit D) and complementary to our companion report...

    Bhagyashree Swarge, Chahida Nafid, Norbert Vischer, Gertjan Kramer, Peter Setlow, Stanley Brul

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