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  • Articles
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    • COVID-19 Research and News from ASM Journals
    • mSphere of Influence: Commentaries from Early Career Microbiologists
    • Archive
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Molecular Biology and Physiology

  • Open Access
    Coexistence of Communicating and Noncommunicating Cells in the Filamentous Cyanobacterium <em>Anabaena</em>
    Research Article | Molecular Biology and Physiology
    Coexistence of Communicating and Noncommunicating Cells in the Filamentous Cyanobacterium Anabaena

    Multicellularity is found in bacteria as well as in eukaryotes, and the filamentous heterocyst-forming (N2-fixing) cyanobacteria represent a simple and ancient paradigm of multicellular organisms. Multicellularity generally involves cell-cell adhesion and communication.

    Sergio Arévalo, Anja Nenninger, Mercedes Nieves-Morión, Antonia Herrero, Conrad W. Mullineaux, Enrique Flores
  • Open Access
    Phosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria Parasites
    Research Article | Molecular Biology and Physiology
    Phosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria Parasites

    Plasmodium falciparum is the deadliest human parasite that causes malaria when it reaches the bloodstream and begins proliferating inside red blood cells, where the parasites are particularly prone to DNA damage. The molecular mechanisms that allow these pathogens to maintain their genome integrity under such conditions are also the driving force for acquiring genome...

    Manish Goyal, Adina Heinberg, Vera Mitesser, Sofiya Kandelis-Shalev, Brajesh Kumar Singh, Ron Dzikowski
  • Open Access
    Coexpression of MmpS5 and MmpL5 Contributes to Both Efflux Transporter MmpL5 Trimerization and Drug Resistance in <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span>
    Research Article | Molecular Biology and Physiology
    Coexpression of MmpS5 and MmpL5 Contributes to Both Efflux Transporter MmpL5 Trimerization and Drug Resistance in Mycobacterium tuberculosis

    It has been reported that mycobacterial membrane protein large 5 (MmpL5), a resistance-nodulation-division (RND)-type inner membrane transporter in Mycobacterium tuberculosis (Mtb), is involved in the transport of antimycobacterial drugs. However, the functional roles of the membrane fusion protein mycobacterial membrane protein small 5 (MmpS5), organized as...

    Kentaro Yamamoto, Noboru Nakata, Tetsu Mukai, Ikuro Kawagishi, Manabu Ato
  • Open Access
    The Two-Component System CopRS Maintains Subfemtomolar Levels of Free Copper in the Periplasm of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Using a Phosphatase-Based Mechanism
    Research Article | Molecular Biology and Physiology
    The Two-Component System CopRS Maintains Subfemtomolar Levels of Free Copper in the Periplasm of Pseudomonas aeruginosa Using a Phosphatase-Based Mechanism

    Copper is a micronutrient required as cofactor in redox enzymes. When free, copper is toxic, mismetallating proteins and generating damaging free radicals.

    Lorena Novoa-Aponte, Cheng Xu, Fernando C. Soncini, José M. Argüello
  • Open Access
    Crucial Role of ppGpp in the Resilience of <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> to Growth Disruption
    Research Article | Molecular Biology and Physiology
    Crucial Role of ppGpp in the Resilience of Escherichia coli to Growth Disruption

    The capacity of microbes to resist and overcome environmental insults, known as resilience, allows them to survive in changing environments but also to resist antibiotic and biocide treatments and immune system responses. Although the role of the stringent response in bacterial resilience to nutritional stresses has been well studied, little is known about its importance in the ability of the bacteria to not just resist but also recover...

    Clément Patacq, Nicolas Chaudet, Fabien Létisse
  • Open Access
    Analysis of Serial Multidrug-Resistant Tuberculosis Strains Causing Treatment Failure and Within-Host Evolution by Whole-Genome Sequencing
    Research Article | Molecular Biology and Physiology
    Analysis of Serial Multidrug-Resistant Tuberculosis Strains Causing Treatment Failure and Within-Host Evolution by Whole-Genome Sequencing

    Few studies have focused on the reasons for the low cure rate of multidrug-resistant tuberculosis in China and within-host evolution during treatment, which is of great significance for improving clinical treatment regimens. Acquired resistance events were common during the ineffective treatment, among which resistance to amikacin and high-level moxifloxacin were the most common.

    Xinchang Chen, Guiqing He, Siran Lin, Shiyong Wang, Feng Sun, Jiazhen Chen, Wenhong Zhang
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Haloferax volcanii</span> Immersed Liquid Biofilms Develop Independently of Known Biofilm Machineries and Exhibit Rapid Honeycomb Pattern Formation
    Research Article | Molecular Biology and Physiology
    Haloferax volcanii Immersed Liquid Biofilms Develop Independently of Known Biofilm Machineries and Exhibit Rapid Honeycomb Pattern Formation

    This first molecular biological study of archaeal immersed liquid biofilms advances our basic biological understanding of the model archaeon Haloferax volcanii. Data gleaned from this study also provide an invaluable foundation for future studies to uncover components required for immersed liquid biofilms in this haloarchaeon and also potentially for liquid biofilm...

    Heather Schiller, Stefan Schulze, Zuha Mutan, Charlotte de Vaulx, Catalina Runcie, Jessica Schwartz, Theopi Rados, Alexandre W. Bisson Filho, Mechthild Pohlschroder
  • Open Access
    The Polyphosphate Kinase of <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Is Required for Full Production of the Genotoxin Colibactin
    Research Article | Molecular Biology and Physiology
    The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin

    Colibactin-producing E. coli induces DNA damage in eukaryotic cells and promotes tumor formation in mouse models of intestinal inflammation. Recent studies have provided strong evidence supporting the causative role of colibactin in human colorectal cancer (CRC) progression.

    Min Tang-Fichaux, Camille V. Chagneau, Nadège Bossuet-Greif, Jean-Philippe Nougayrède, Éric Oswald, Priscilla Branchu
  • Open Access
    Enzymatic Analysis of Yeast Cell Wall-Resident GAPDH and Its Secretion
    Research Article | Molecular Biology and Physiology
    Enzymatic Analysis of Yeast Cell Wall-Resident GAPDH and Its Secretion

    Eukaryotic cells secrete many proteins, including many proteins that do not follow the classical secretion pathway. Among these, the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is unexpectedly found in the walls of yeasts and other fungi and in extracellular space in mammalian cell cultures.

    Michael J. Cohen, Brianne Philippe, Peter N. Lipke
  • Open Access
    Suppressor Mutations in Type II Secretion Mutants of <span class="named-content genus-species" id="named-content-1">Vibrio cholerae</span>: Inactivation of the VesC Protease
    Research Article | Molecular Biology and Physiology
    Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease

    Genome-wide transposon mutagenesis has identified the genes encoding the T2SS in Vibrio cholerae as essential for viability, but the reason for this is unclear. Mutants with deletions or insertions in these genes can be isolated, suggesting that they have acquired secondary mutations that suppress their growth defect.

    Chelsea S. Rule, Young-Jun Park, Jaclyn R. Delarosa, Stewart Turley, Wim G. J. Hol, Sarah McColm, Colby Gura, Frank DiMaio, Konstantin V. Korotkov, Maria Sandkvist

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