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  • Articles
    • Latest Articles
    • COVID-19 Research and News from ASM Journals
    • mSphere of Influence: Commentaries from Early Career Microbiologists
    • Archive
  • Topics
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Host-Microbe Biology

  • Open Access
    Biotinylated Surfome Profiling Identifies Potential Biomarkers for Diagnosis and Therapy of <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span> Infection
    Research Article | Host-Microbe Biology
    Biotinylated Surfome Profiling Identifies Potential Biomarkers for Diagnosis and Therapy of Aspergillus fumigatus Infection

    Aspergillus fumigatus is the most important airborne human-pathogenic mold, capable of causing both life-threatening invasive pulmonary aspergillosis in immunocompromised patients and allergy-inducing infections in individuals with atopic allergy. Despite its obvious medical relevance, timely diagnosis and efficient antifungal treatment of...

    Lei-Jie Jia, Thomas Krüger, Matthew G. Blango, Ferdinand von Eggeling, Olaf Kniemeyer, Axel A. Brakhage
  • Open Access
    Identification of Genomewide Alternative Splicing Events in Sequential, Isogenic Clinical Isolates of <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Reveals a Novel Mechanism of Drug Resistance and Tolerance to Cellular Stresses
    Research Article | Host-Microbe Biology
    Identification of Genomewide Alternative Splicing Events in Sequential, Isogenic Clinical Isolates of Candida albicans Reveals a Novel Mechanism of Drug Resistance and Tolerance to Cellular Stresses

    The emergence of resistance in Candida albicans, an opportunistic pathogen, against the commonly used antifungals is becoming a major obstacle in its treatment. The necessity to identify new drug targets demands fundamental insights into the mechanisms used by this organism to develop drug resistance. C....

    Suraya Muzafar, Ravi Datta Sharma, Abdul Haseeb Shah, Naseem A. Gaur, Ujjaini Dasgupta, Neeraj Chauhan, Rajendra Prasad
  • Open Access
    MARTX Toxin-Stimulated Interplay between Human Cells and <span class="named-content genus-species" id="named-content-1">Vibrio vulnificus</span>
    Research Article | Host-Microbe Biology
    MARTX Toxin-Stimulated Interplay between Human Cells and Vibrio vulnificus

    V. vulnificus is an opportunistic human pathogen that can cause life-threatening sepsis in immunocompromised patients via seafood poisoning or wound infection. Among the toxic substances produced by this pathogen, the MARTX toxin greatly contributes to disease progression by promoting the dysfunction and death of host cells, which allows the bacteria to disseminate...

    Byoung Sik Kim, Jong-Hwan Kim, Sanghyeon Choi, Shinhye Park, Eun-Young Lee, Serry Koh, Choong-Min Ryu, Seon-Young Kim, Myung Hee Kim
  • Open Access
    Tn-Seq Analysis Identifies Genes Important for <span class="named-content genus-species" id="named-content-1">Yersinia pestis</span> Adherence during Primary Pneumonic Plague
    Research Article | Host-Microbe Biology
    Tn-Seq Analysis Identifies Genes Important for Yersinia pestis Adherence during Primary Pneumonic Plague

    Colonization of the lung by Yersinia pestis is a critical first step in establishing infection during primary pneumonic plague, a disease characterized by high lethality. However, the mechanisms by which Y. pestis adheres in the lung after inhalation remain elusive. Here, we used Tn-seq to identify...

    Kara R. Eichelberger, Victoria E. Sepúlveda, John Ford, Sara R. Selitsky, Piotr A. Mieczkowski, Joel S. Parker, William E. Goldman
  • Open Access
    Bacteria Modify <em>Candida albicans</em> Hypha Formation, Microcolony Properties, and Survival within Macrophages
    Research Article | Host-Microbe Biology
    Bacteria Modify Candida albicans Hypha Formation, Microcolony Properties, and Survival within Macrophages

    Candida albicans is the predominant fungus colonizing the oral cavity that can have both synergistic and antagonistic interactions with other bacteria. Interkingdom polymicrobial associations modify fungal pathogenicity and are believed to increase microbial resistance to innate immunity. However, it is not known how these interactions alter fungal survival during...

    Ornella Salvatori, Rohitashw Kumar, Sarah Metcalfe, Margaret Vickerman, Jason G. Kay, Mira Edgerton
  • Open Access
    Comparative Evaluations of the Pathogenesis of <span class="named-content genus-species" id="named-content-1">Candida auris</span> Phenotypes and <span class="named-content genus-species" id="named-content-2">Candida albicans</span> Using Clinically Relevant Murine Models of Infections
    Research Article | Host-Microbe Biology
    Comparative Evaluations of the Pathogenesis of Candida auris Phenotypes and Candida albicans Using Clinically Relevant Murine Models of Infections

    The newly emerged Candida species C. auris has been associated with an exponential rise in invasive disease in health care facilities worldwide with a mortality rate approaching 60%. C. auris exhibits a high level of transmissibility, multidrug resistance, and persistence in hospital...

    Taissa Vila, Daniel Montelongo-Jauregui, Hussian Ahmed, Taanya Puthran, Ahmed S. Sultan, Mary Ann Jabra-Rizk
  • Open Access
    A Critical Role for Perivascular Cells in Amplifying Vascular Leakage Induced by Dengue Virus Nonstructural Protein 1
    Research Article | Host-Microbe Biology
    A Critical Role for Perivascular Cells in Amplifying Vascular Leakage Induced by Dengue Virus Nonstructural Protein 1

    The World Health Organization considers dengue one of the top 10 global public health problems. There is no specific antiviral therapy to treat dengue virus and no way of predicting which patients will develop potentially fatal severe dengue, typified by vascular leakage and circulatory shock. We show here that perivascular cells (pericytes) amplify the vascular leakage-inducing effects of the dengue viral protein NS1 through contact-...

    Yin P. Cheung, Valeria Mastrullo, Davide Maselli, Teemapron Butsabong, Paolo Madeddu, Kevin Maringer, Paola Campagnolo
  • Open Access
    Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and <em>UL138</em> Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways
    Research Article | Host-Microbe Biology
    Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

    Human cytomegalovirus (HCMV) causes significant disease in immunocompromised individuals, including transplant patients. HCMV establishes latency in hematopoietic stem cells in the bone marrow. The mechanisms governing latency and reactivation of viral replication are complex and not fully understood. HCMV-encoded miRNAs are small regulatory RNAs that reduce protein expression. In this study, we found that the HCMV miRNA miR-US5-2...

    Meaghan H. Hancock, Jennifer Mitchell, Felicia D. Goodrum, Jay A. Nelson
  • Open Access
    Molecular Elucidation of Riboflavin Production and Regulation in <span class="named-content genus-species" id="named-content-1">Candida albicans</span>, toward a Novel Antifungal Drug Target
    Editor's Pick Research Article | Host-Microbe Biology
    Molecular Elucidation of Riboflavin Production and Regulation in Candida albicans, toward a Novel Antifungal Drug Target

    Candida albicans is an important fungal pathogen causing common superficial infections as well as invasive diseases with an extremely high morbidity and mortality. Antifungal therapies are limited in efficiency and availability. In this research, we describe the regulation of riboflavin production in C....

    Liesbeth Demuyser, Ilse Palmans, Paul Vandecruys, Patrick Van Dijck
  • Open Access
    Natural Infection with <em>Giardia</em> Is Associated with Altered Community Structure of the Human and Canine Gut Microbiome
    Research Article | Host-Microbe Biology
    Natural Infection with Giardia Is Associated with Altered Community Structure of the Human and Canine Gut Microbiome

    While enteric parasitic infections are among the most important infections in lower- and middle-income countries, their impact on gut microbiota is poorly understood. We reasoned that clinical symptoms associated with these infections may be influenced by alterations of the microbiome that occur during infection. To explore this notion, we took a two-pronged approach. First, we studied a cohort of dogs naturally infected with various...

    Alexander S. F. Berry, Kaylynn Johnson, Rene Martins, Megan C. Sullivan, Camila Farias Amorim, Alexandra Putre, Aiysha Scott, Shuai Wang, Brianna Lindsay, Robert N. Baldassano, Thomas J. Nolan, Daniel P. Beiting

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