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Clinical Science and Epidemiology

  • Open Access
    Tuberculosis under the Influence of COVID-19 Lockdowns: Lessons from Tehran, Iran
    Perspective | Clinical Science and Epidemiology
    Tuberculosis under the Influence of COVID-19 Lockdowns: Lessons from Tehran, Iran

    This study investigates the short-term effects of the coronavirus disease 2019 (COVID-19) pandemic lockdown on tracing and detection of tuberculosis (TB) patients in Tehran, Iran. Results of this study have demonstrated that due to the significant decrease in the identification of patients with suspected TB during the COVID-19 outbreak in Tehran, it is imperative that patients with suspected TB be tracked and diagnosed more quickly to...

    Mansour Kargarpour Kamakoli, Shima Hadifar, Sharareh Khanipour, Ghazaleh Farmanfarmaei, Abolfazl Fateh, Shayan Mostafaei, Seyed Davar Siadat, Farzam Vaziri
  • Open Access
    Clinical and Molecular Epidemiology of an Emerging Panton-Valentine Leukocidin-Positive ST5 Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Clone in Northern Australia
    Research Article | Clinical Science and Epidemiology
    Clinical and Molecular Epidemiology of an Emerging Panton-Valentine Leukocidin-Positive ST5 Methicillin-Resistant Staphylococcus aureus Clone in Northern Australia

    Staphylococcus aureus is an important human pathogen that causes a wide range of clinical infections. In the past 2 decades, an epidemic of community-associated skin and soft tissue infections has been driven by S. aureus strains with specific virulence factors and resistance to beta-lactam...

    Sarah L. McGuinness, Deborah C. Holt, Tegan M. Harris, Connor Wright, Rob Baird, Phillip M. Giffard, Asha C. Bowen, Steven Y. C. Tong
  • Open Access
    Molecular Evolution of Human Coronavirus 229E in Hong Kong and a Fatal COVID-19 Case Involving Coinfection with a Novel Human Coronavirus 229E Genogroup
    Research Article | Clinical Science and Epidemiology
    Molecular Evolution of Human Coronavirus 229E in Hong Kong and a Fatal COVID-19 Case Involving Coinfection with a Novel Human Coronavirus 229E Genogroup

    Since its first appearance in the 1960s, the genetic diversity and evolution of human coronavirus 229E (HCoV-229E) have been relatively understudied. In this study, we report a fatal case of COVID-19 coinfected with HCoV-229E in Hong Kong.

    Susanna K. P. Lau, David C. Lung, Emily Y. M. Wong, Kam Leng Aw-Yong, Antonio C. P. Wong, Hayes K. H. Luk, Kenneth S. M. Li, Joshua Fung, Tony T. Y. Chan, James Y. M. Tang, Longchao Zhu, Cyril C. Y. Yip, Sally C. Y. Wong, Rodney A. Lee, Owen T. Y. Tsang, Kwok-Yung Yuen, Patrick C. Y. Woo
  • Open Access
    Genomic Diversity of <span class="named-content genus-species" id="named-content-1">Burkholderia pseudomallei</span> in Ceara, Brazil
    Research Article | Clinical Science and Epidemiology
    Genomic Diversity of Burkholderia pseudomallei in Ceara, Brazil

    B. pseudomallei causes significant morbidity and mortality, but its geographic prevalence and genetic diversity are not well characterized, especially in the Western Hemisphere. A better understanding of the genetic relationships among clinical and environmental isolates will improve knowledge of the population structure of this bacterium as well as the ability to...

    Jay E. Gee, Christopher A. Gulvik, Debora S. C. M. Castelo-Branco, José J. C. Sidrim, Marcos F. G. Rocha, Rossana A. Cordeiro, Raimunda S. N. Brilhante, Tereza J. P. G. Bandeira, Iracema Patrício, Lucas P. Alencar, Ana Karoline da Costa Ribeiro, Mili Sheth, Mark A. Deka, Alex R. Hoffmaster, Dionne Rolim
  • Open Access
    Seroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USA
    Research Article | Clinical Science and Epidemiology
    Seroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USA

    This study determined the percentages of both children and adult samples from the greater St. Louis metropolitan area who had antibodies to SARS-CoV-2 in late April to early May 2020.

    Brittany K. Smith, Andrew B. Janowski, Jonathan E. Danis, Ian B. Harvey, Haiyan Zhao, Ya-Nan Dai, Christopher W. Farnsworth, Ann M. Gronowski, Stephen Roper, Daved H. Fremont, David Wang
  • Open Access
    Ceftolozane/Tazobactam Resistance and Mechanisms in Carbapenem-Nonsusceptible <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span>
    Research Article | Clinical Science and Epidemiology
    Ceftolozane/Tazobactam Resistance and Mechanisms in Carbapenem-Nonsusceptible Pseudomonas aeruginosa

    Pseudomonas aeruginosa infection is one of the most difficult health care-associated infections to treat due to the ability of the organism to acquire a multitude of resistance mechanisms and express the multidrug resistance phenotype. Ceftolozane/tazobactam (C/T), a novel β-lactam/β-lactamase inhibitor combination, addresses an unmet medical need in...

    Jocelyn Qi-Min Teo, Jie Chong Lim, Cheng Yee Tang, Shannon Jing-Yi Lee, Si Hui Tan, James Heng-Chiak Sim, Rick Twee-Hee Ong, Andrea Lay-Hoon Kwa
  • Open Access
    Complete Genome Sequencing of <span class="named-content genus-species" id="named-content-1">Acinetobacter baumannii</span> AC1633 and <span class="named-content genus-species" id="named-content-2">Acinetobacter nosocomialis</span> AC1530 Unveils a Large Multidrug-Resistant Plasmid Encoding the NDM-1 and OXA-58 Carbapenemases
    Research Article | Clinical Science and Epidemiology
    Complete Genome Sequencing of Acinetobacter baumannii AC1633 and Acinetobacter nosocomialis AC1530 Unveils a Large Multidrug-Resistant Plasmid Encoding the NDM-1 and OXA-58 Carbapenemases

    Bacteria of the genus Acinetobacter are important hospital-acquired pathogens, with carbapenem-resistant A. baumannii listed by the World Health Organization as the one of the top priority pathogens. Whole-genome sequencing of carbapenem-resistant...

    Ahmed Ghazi Alattraqchi, Farahiyah Mohd Rani, Nor Iza A. Rahman, Salwani Ismail, David W. Cleary, Stuart C. Clarke, Chew Chieng Yeo
  • Open Access
    Interplay of Antibody and Cytokine Production Reveals CXCL13 as a Potential Novel Biomarker of Lethal SARS-CoV-2 Infection
    Research Article | Clinical Science and Epidemiology
    Interplay of Antibody and Cytokine Production Reveals CXCL13 as a Potential Novel Biomarker of Lethal SARS-CoV-2 Infection

    The SARS-CoV-2 pandemic is continuing to impact the global population, and knowledge of the immune response to COVID-19 is still developing. This study assesses the interplay of different parts of the immune system during COVID-19 disease.

    Alexander M. Horspool, Theodore Kieffer, Brynnan P. Russ, Megan A. DeJong, M. Allison Wolf, Jacqueline M. Karakiozis, Brice J. Hickey, Paolo Fagone, Danyel H. Tacker, Justin R. Bevere, Ivan Martinez, Mariette Barbier, Peter L. Perrotta, F. Heath Damron
  • Open Access
    A Novel N4-Like Bacteriophage Isolated from a Wastewater Source in South India with Activity against Several Multidrug-Resistant Clinical <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Isolates
    Research Article | Clinical Science and Epidemiology
    A Novel N4-Like Bacteriophage Isolated from a Wastewater Source in South India with Activity against Several Multidrug-Resistant Clinical Pseudomonas aeruginosa Isolates

    In India, multidrug resistance determinants are much more abundant in community-associated bacterial pathogens due to the improper treatment of domestic and industrial effluents. In particular, a high bacterial load of the opportunistic pathogen P. aeruginosa in sewage and water bodies in India is well documented.

    Nitasha D. Menon, Megha S. Kumar, T. G. Satheesh Babu, Sucharita Bose, Gayathri Vijayakumar, Manasi Baswe, Meghna Chatterjee, Jovita Rowena D’Silva, Kavya Shetty, Jayalekshmi Haripriyan, Anil Kumar, Samitha Nair, Priyanka Somanath, Bipin G. Nair, Victor Nizet, Geetha B. Kumar
  • Open Access
    OXA-181-Like Carbapenemases in <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> ST14, ST15, ST23, ST48, and ST231 from Septicemic Neonates: Coexistence with NDM-5, Resistome, Transmissibility, and Genome Diversity
    Research Article | Clinical Science and Epidemiology
    OXA-181-Like Carbapenemases in Klebsiella pneumoniae ST14, ST15, ST23, ST48, and ST231 from Septicemic Neonates: Coexistence with NDM-5, Resistome, Transmissibility, and Genome Diversity

    Neonatal sepsis is a leading cause of neonatal mortality in low- and middle-income countries (LMICs). Treatment of sepsis in this vulnerable population is dependent on antimicrobials, and resistance to these life-saving antimicrobials is worrisome.

    Sharmi Naha, Kirsty Sands, Subhankar Mukherjee, Bijan Saha, Shanta Dutta, Sulagna Basu

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