Skip to main content
  • ASM Journals
    • Antimicrobial Agents and Chemotheraphy
    • Applied and Environmental Mircobiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Genome Announcements
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
Advertisement

Main menu

  • Home
  • Articles
    • Latest Articles
    • Archive
  • Topics
    • Applied and Environmental Science
    • Clinical Science and Epidemiology
    • Ecological and Evolutionary Science
    • Host-Microbe Biology
    • Molecular Biology and Physiology
    • Therapeutics and Prevention
  • For Authors
    • Getting Started
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Portal
  • About the Journal
    • About mSphere
    • mSphereDirect
    • Editor-in-Chief
    • Board of Editors
    • Data Policy
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • ASM Journals
    • Antimicrobial Agents and Chemotheraphy
    • Applied and Environmental Mircobiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Genome Announcements
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts

Search

  • Advanced search
mSphere

mSphere

Advanced Search

  • Home
  • Articles
    • Latest Articles
    • Archive
  • Topics
    • Applied and Environmental Science
    • Clinical Science and Epidemiology
    • Ecological and Evolutionary Science
    • Host-Microbe Biology
    • Molecular Biology and Physiology
    • Therapeutics and Prevention
  • For Authors
    • Getting Started
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Portal
  • About the Journal
    • About mSphere
    • mSphereDirect
    • Editor-in-Chief
    • Board of Editors
    • Data Policy
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ

virulence

  • <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span><em> gshA</em> Mutant Is Defective in Biofilm Formation, Swarming, and Pyocyanin Production
    Research Article | Molecular Biology and Physiology
    Pseudomonas aeruginosa gshA Mutant Is Defective in Biofilm Formation, Swarming, and Pyocyanin Production

    Pseudomonas aeruginosa is a ubiquitous bacterium that can cause severe opportunistic infections, including many hospital-acquired infections. It is also a major cause of infections in patients with cystic fibrosis. P. aeruginosa is intrinsically resistant to a number of drugs and is capable of...

    Tricia A. Van Laar, Saika Esani, Tyler J. Birges, Bethany Hazen, Jason M. Thomas, Mamta Rawat
    18 Apr 2018
  • Targeting Virulence in <em>Staphylococcus aureus</em> by Chemical Inhibition of the Accessory Gene Regulator System <em>In Vivo</em>
    Minireview | Therapeutics and Prevention
    Targeting Virulence in Staphylococcus aureus by Chemical Inhibition of the Accessory Gene Regulator System In Vivo

    Methicillin-resistant Staphylococcus aureus (MRSA) presents one of the most serious health concerns worldwide. The WHO labeled it as a “high-priority” pathogen in 2017, also citing the more recently emerged vancomycin-intermediate and -resistant strains.

    Akram M. Salam, Cassandra L. Quave
    17 Jan 2018
  • The <em>Candida albicans</em> TOR-Activating GTPases Gtr1 and Rhb1 Coregulate Starvation Responses and Biofilm Formation
    Research Article | Host-Microbe Biology
    The Candida albicans TOR-Activating GTPases Gtr1 and Rhb1 Coregulate Starvation Responses and Biofilm Formation

    Candida albicans is the major fungal pathogen of humans and is responsible for a wide range of infections, including life-threatening systemic infections in susceptible hosts. Target of rapamycin complex 1 (TORC1) is an essential regulator of metabolism in this fungus, and components of this complex are under increased investigation as targets for new antifungal drugs. The present study characterized the role of GTR1,...

    Peter R. Flanagan, Ning-Ning Liu, Darren J. Fitzpatrick, Karsten Hokamp, Julia R. Köhler, Gary P. Moran
    15 Nov 2017
  • Grf10 and Bas1 Regulate Transcription of Adenylate and One-Carbon Biosynthesis Genes and Affect Virulence in the Human Fungal Pathogen <em>Candida albicans</em>
    Research Article | Molecular Biology and Physiology
    Grf10 and Bas1 Regulate Transcription of Adenylate and One-Carbon Biosynthesis Genes and Affect Virulence in the Human Fungal Pathogen Candida albicans

    Candida albicans is a commensal and a common constituent of the human microbiota; however, it can become pathogenic and cause infections in both immunocompetent and immunocompromised people. C. albicans exhibits remarkable metabolic versatility as it can colonize multiple body sites as a commensal or pathogen. Understanding how C. albicans adapts metabolically to each ecological niche is essential for...

    Tanaporn Wangsanut, Anup K. Ghosh, Peter G. Metzger, William A. Fonzi, Ronda J. Rolfes
    02 Aug 2017
  • Opacification Domain of Serum Opacity Factor Inhibits Beta-Hemolysis and Contributes to Virulence of <em>Streptococcus pyogenes</em>
    Research Article | Host-Microbe Biology
    Opacification Domain of Serum Opacity Factor Inhibits Beta-Hemolysis and Contributes to Virulence of Streptococcus pyogenes

    Streptococcus pyogenes is a major human pathogen causing more than 700 million infections annually. As a successful pathogen, S. pyogenes produces many virulence factors that facilitate colonization, proliferation, dissemination, and tissue damage. Serum opacity factor (SOF), an extracellular protein, is one of the virulence factors made by S. pyogenes. The underlying mechanism of how SOF contributes to...

    Luchang Zhu, Randall J. Olsen, James M. Musser
    19 Apr 2017
  • Staurosporine Induces Filamentation in the Human Fungal Pathogen <em>Candida albicans</em> via Signaling through Cyr1 and Protein Kinase A
    Research Article | Molecular Biology and Physiology
    Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A

    The impact of fungal pathogens on human health is devastating. One of the most pervasive fungal pathogens is Candida albicans, which kills ~40% of people suffering from bloodstream infections. Treatment of these infections is extremely difficult, as fungi are closely related to humans, and there are limited drugs that kill the fungus without host toxicity. The capacity of C. albicans to transition between yeast and...

    Jinglin L. Xie, Teresa R. O’Meara, Elizabeth J. Polvi, Nicole Robbins, Leah E. Cowen
    01 Mar 2017
  • The Pathogenic Potential of a Microbe
    Editor's Pick Opinion/Hypothesis | Host-Microbe Biology
    The Pathogenic Potential of a Microbe
    Arturo Casadevall
    22 Feb 2017
  • New Insights into Autoinducer-2 Signaling as a Virulence Regulator in a Mouse Model of Pneumonic Plague
    Research Article | Host-Microbe Biology
    New Insights into Autoinducer-2 Signaling as a Virulence Regulator in a Mouse Model of Pneumonic Plague

    Yersinia pestis is the bacterial agent that causes the highly fatal disease plague. The organism represents a significant concern because of its potential use as a bioterror agent, beyond the several thousand naturally occurring human infection cases occurring globally each year. While there has been development of effective antibiotics, the narrow therapeutic window and challenges posed by the existence of antibiotic-resistant...

    Eric C. Fitts, Jourdan A. Andersson, Michelle L. Kirtley, Jian Sha, Tatiana E. Erova, Sadhana Chauhan, Vladimir L. Motin, Ashok K. Chopra
    14 Dec 2016
  • Characterization of <em>Aspergillus fumigatus</em> Isolates from Air and Surfaces of the International Space Station
    Editor's Pick Research Article | Clinical Science and Epidemiology
    Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station

    As durations of manned space missions increase, it is imperative to understand the long-term consequence of microbial exposure on human health in a closed human habitat. To date, studies aimed at bacterial and fungal contamination of space vessels have highlighted species compositions biased toward hardy, persistent organisms capable of withstanding harsh conditions. In the current study, we assessed traits of two independent ...

    Benjamin P. Knox, Adriana Blachowicz, Jonathan M. Palmer, Jillian Romsdahl, Anna Huttenlocher, Clay C. C. Wang, Nancy P. Keller, Kasthuri Venkateswaran
    26 Oct 2016
  • DNA from Dust: Comparative Genomics of Large DNA Viruses in Field Surveillance Samples
    Resource Report | Ecological and Evolutionary Science
    DNA from Dust: Comparative Genomics of Large DNA Viruses in Field Surveillance Samples

    Despite both clinical and laboratory data that show increased virulence in field isolates of MDV-1 over the last half century, we do not yet understand the genetic basis of its pathogenicity. Our knowledge of genome-wide variation between strains of this virus comes exclusively from isolates that have been cultured in the laboratory. MDV-1 isolates tend to lose virulence during repeated cycles of replication in the laboratory, raising...

    Utsav Pandey, Andrew S. Bell, Daniel W. Renner, David A. Kennedy, Jacob T. Shreve, Chris L. Cairns, Matthew J. Jones, Patricia A. Dunn, Andrew F. Read, Moriah L. Szpara
    05 Oct 2016

Pages

  • Next
  • 1
  • 2
Back to top

About the Journal

  • About mSphere
  • mSphereDirect
  • Board of Editors
  • Data Policy
  • For Reviewers
  • For the Media
  • Embargo Policy
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ

For Authors

  • Submit a Manuscript
  • Author Warranty
  • Types of Articles
  • Getting Started
  • Contact Us
  • Ethics Portal

Follow #mSphereJ

@ASMicrobiology

       

 

Website feedback

Journals.ASM.org

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

1752 N Street N.W.
Washington DC 20036
202.737.3600
202.942.9355 fax
journals@asmusa.org

Copyright © 2018 American Society for Microbiology   eISSN 2379-5042