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efflux pumps

  • High Salt Cross-Protects <em>Escherichia coli</em> from Antibiotic Treatment through Increasing Efflux Pump Expression
    Research Article | Molecular Biology and Physiology
    High Salt Cross-Protects Escherichia coli from Antibiotic Treatment through Increasing Efflux Pump Expression

    Environmental stresses often co-occur when bacteria confront antibiotic treatment. We provide a clear example that a natural stress condition (high salt) can cross-protect bacteria from antibiotic treatment by triggering the bacterial stress response program (elevated AcrAB-TolC efflux pump expression). Our study highlights the importance of taking the co-occurrence of bacterial environmental stresses into consideration when...

    Manlu Zhu, Xiongfeng Dai
    11 Apr 2018
  • Plasticity of the <em>MFS1</em> Promoter Leads to Multidrug Resistance in the Wheat Pathogen <em>Zymoseptoria tritici</em>
    Research Article | Applied and Environmental Science
    Plasticity of the MFS1 Promoter Leads to Multidrug Resistance in the Wheat Pathogen Zymoseptoria tritici

    Disease control through fungicides remains an important means to protect crops from fungal diseases and to secure the harvest. Plant-pathogenic fungi, especially Zymoseptoria tritici, have developed resistance against most currently used active ingredients, reducing or abolishing their efficacy. While target site modification is the most common resistance mechanism against single modes of action, active efflux of multiple drugs...

    Selim Omrane, Colette Audéon, Amandine Ignace, Clémentine Duplaix, Lamia Aouini, Gert Kema, Anne-Sophie Walker, Sabine Fillinger
    25 Oct 2017
  • The Biofilm Inhibitor Carolacton Enters Gram-Negative Cells: Studies Using a TolC-Deficient Strain of <em>Escherichia coli</em>
    Research Article | Therapeutics and Prevention
    The Biofilm Inhibitor Carolacton Enters Gram-Negative Cells: Studies Using a TolC-Deficient Strain of Escherichia coli

    The emergence of pathogens resistant against most or all of the antibiotics currently used in human therapy is a global threat, and therefore the search for antimicrobials with novel targets and modes of action is of utmost importance. The myxobacterial secondary metabolite carolacton had previously been shown to inhibit biofilm formation and growth of streptococci. Here, we investigated if carolacton could act against Gram-negative...

    Jannik Donner, Michael Reck, Boyke Bunk, Michael Jarek, Constantin Benjamin App, Jan P. Meier-Kolthoff, Jörg Overmann, Rolf Müller, Andreas Kirschning, Irene Wagner-Döbler
    27 Sep 2017
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