TABLE 3 

Density of pneumococcal nasopharyngeal carriage in PCV7-vaccinated and PCV7-unvaccinated, HIV-uninfected children as measured by quantitative PCR

PneumococcusGMD (95% CI)a in 9-mo-old childrenP value GMD (95% CI) in 16-mo-old children P value
PCV7-unvaccinated
(n = 181)
PCV7-vaccinated
(n = 175)
PCV7-unvaccinated
(n = 193)
PCV7-vaccinated
(n = 164)
Pneumococcus (LytA)4.28 (4.09 to 4.47)4.68 (4.45 to 4.90)0.0074.33 (4.16 to 4.5)4.44 (4.23 to 4.66)0.53
Vaccine serotypes/
serogroups
3.4 (3.2 to 3.6)3.8 (3.5 to 4.1)0.0483.59 (3.36 to 3.83)3.73 (3.4 to 4.0)0.48
    43.82.18 (−2.1 to 6.47)4.53
    6A/B4.41 (4.0 to 4.82)4.41 (3.9 to 4.92)0.994.17 (3.66 to 4.68)4.0 (3.44 to 4.58)0.68
    9A/L/N/V2.52 (1.96 to 3.08)2.84 (1.48 to 4.19)0.522.36 (1.77 to 2.96)3.99 (0.81 to 6.04)0.09
    142.46 (1.7 to 3.22)3.66 (−0.68 to 6.65)0.153.29 (2.68 to 3.91)2.75 (1.29 to 4.20)0.37
    18A/B/C2.80 (2.26 to 3.49)1.963.58 (2.51 to 4.65)4.30 (3.36 to 5.25)0.32
    19B/F3.36 (2.99 to 3.74)3.79 (3.28 to 4.3)0.163.52 (3.12 to 3.96)3.65 (3.12 to 4.17)0.71
    23F2.9 (2.59 to 3.4)3.76 (2.24 to 5.28)0.843.04 (2.67 to 3.4)3.44 (2.45 to 4.44)0.71
Nonvaccine
serotypes/
serogroups
3.1 (2.7 to 3.4)3.6 (3.0 to 3.4)0.0183.33 (3.0 to 3.66)3.74 (3.42 to 4.06)0.08
    12.312.29 (−1.03 to 5.61)3.47 (−11.4 to 8.31)1.99
    35.133.55
    52.0 (1.63 to 2.36)2.29 (1.85 to 2.7)0.232.01 (1.83 to 2.19)2.79 (1.53 to 4.04)0.015
    6C/D4.2 (−25.5 to 33.94)2.76 (1.71 to 3.81)0.602.99 (2.32 to 3.67)3.99 (−12.12 to 0.1)0.38
    7C3.253.13 (0.5 to 5.76)1.572.66 (1.51 to 3.79)
    10B4.15 (−10.47 to 8.78)3.094.65 (4.0 to 5.3)3.26 (2.15 to 4.36)0.06
    11A/B/C/D/F1.79 (−2.66 to 6.24)2.67 (1.32 to 4.0)0.342.88 (1.9 to 3.87)4.06 (0.82 to 7.3)0.23
    12A/B/F2.443.38 (1.39 to 5.38)
    132.99 (0.22 to 6.01)4.7 (2.86 to 6.54)0.212.84 (1.08 to 4.61)3.21 (1.38 to 5.04)0.65
    15A/B/C/F3.66 (3.11 to 4.2)4.1 (3.4 to 4.79)0.273.88 (3.23 to 4.53)4.03 (3.27 to 4.79)0.75
    16F3.26 (2.24 to 4.28)3.65 (2.4 to 4.89)0.654.84 (2.67 to 7.01)5.07 (2.77 to 7.37)0.84
    17F3.10 (−1.31 to 7.5)2.48 (−12.1 to 7.05)0.72
    19A2.83 (2.26 to 3.7)3.76 (3.36 to 4.1)0.0463.04 (2.26 to 3.83)4.15 (3.66 to 4.64)0.013
    204.20 (2.33 to 6.07)2.01
    213.62 (−0.65 to 7.89)3.32 (−13.7 to 0.36)0.875.222.82 (1.82 to 3.8)
    23A/B2.07 (1.48 to 2.67)4.48 (0.82 to 8.14)0.0021.58 (1.28 to 1.87)3.59 (0.88 to 6.32)0.013
    34/37/17A2.83 (1.33 to 4.34)3.76 (2.24 to 5.28)0.844.34 (0.50 to 8.17)4.67 (3.7 to 5.61)0.71
  • a The geometric mean density (GMD) of carriage and 95% confidence intervals (95% CI) were calculated following log10 transformations and compared with multivariate analysis controlling for race, smoking household contact, co-trimoxazole use, day care attendance, and mean age at time of sample collection. PCV7, 7-valent pneumococcal conjugate vaccine. −, too few observations to calculate the P value.