TABLE 4 

Cocolonization by vaccine types and nonvaccine type pneumococcus in HIV-uninfected children as measured by quantitative molecular PCR

Pneumococcal colonizationaCocolonizationb in 9-mo-old childrenP valuecCocolonization in 16-mo-old childrenP value
PCV7-unvaccinated
(n = 181)
PCV7-vaccinated
(n = 175)
PCV7-unvaccinated
(n = 193)
PCV7-vaccinated
(n = 164)
Total 150 (82.9)125 (71.4)0.01157 (81.3)123 (75)0.06
    Not typeabled14 (9.3)22 (17.6)0.0929 (18.5)29 (23.4)0.88
    Single carriers97 (64.6)74 (59.2)0.02579 (50.3)55 (44.7)0.019
    Multiple carriers39 (26)29 (23.2)0.8749 (31.2)39 (31.7)0.63
        +1 VT12 (30.7)4 (13.8)0.00211 (22.4)1 (2.6)0.005
        VT and NVT26 (66.7)18 (62.1)0.00631 (63.2)21 (55.3)0.004
        +1 NVT1 (2.6)7 (24.1)0.0157 (14.3)16 (42)0.002
  • a The total colonizing pneumococci isolated, including nontypeable pneumococci, single carriers, and multiple carriers (carrying more than one VT, VT and NVT, and more than one NVT). VT, vaccine serotypes/serogroups (4, 6A/B, 9A/L/N/V, 18A/B/C, 19B/F, and 23F). NVT, nonvaccine serotypes/serogroups (1, 3, 5, 6 C/D, 7C, 10A, 11A/B/C/D/F, 12A/B/F, 13, 15 A/B/C/F, 16F, 17F, 19A, 20, 21, 23A/B, and 34/37/17A).

  • b The number of children (percentage shown in parentheses) cocolonized who had not been vaccinated or had been vaccinated with 7-valent pneumococcal conjugate vaccine (PCV7).

  • c The P  values were determined by multivariate logistic regression, controlling for race, smoking household contact, co-trimoxazole use, day care attendance, and mean age at time of sample collection. P values of <0.05 were considered significant.

  • d Nontypeable, lytA-positive, serotype-negative samples.