TABLE 3 

Levels of maternal antibodies against Toxoplasma gondii, rubella virus, CMV, HSV-1, and HSV-2 measured in samples collected at midpregnancy and postpartum, stratified by sex of childb

Antibody at timeBoysGirls
ASDControlsP valueASDControlsP value
Midpregnancy (n)3623657799
    Anti-HSV-1295.08 (300.40)288.09 (301.60)0.71281.25 (299.40)327.64 (306.30)0.43
    Anti-HSV-275.99 (173.21)a62.18 (126.33)a0.0271.70 (150.47)72.32 (154.86)0.67
    Anti-CMV198.64 (183.45)197.67 (184.66)0.53192.23 (163.14)171.22 (153.11)0.34
    Anti-Toxoplasma51.10 (102.67)54.62 (106.92)0.1557.71 (108.36)51.82 (100.70)0.53
    Anti-rubella virus79.34 (31.77)82.62 (29.53)0.1081.36 (32.87)80.53 (33.31)0.78
Postpartum (n)3413647499
    Anti-HSV-1277.01 (288.63)259.48 (286.56)0.35262.59 (293.53)307.87 (301.07)0.35
    Anti-HSV-272.43 (165.31)57.59 (130.10)0.1666.47 (157.84)71.60 (155.05)0.92
    Anti-CMV192.58 (186.73)183.56 (173.63)0.82178.71 (164.66)155.25 (141.74)0.55
    Anti-Toxoplasma43.95 (87.22)47.67 (95.71)0.7148.24 (79.94)46.74 (97.47)0.05
    Anti-rubella virus70.32 (29.75)73.94 (29.50)0.0874.67 (31.20)70.92 (32.17)0.38
  • a Mann-Whitney U = 59,636; P = 0.02, two-tailed; adjusted for multiple comparison between pathogens, P = 0.12.

  • b Unless indicated otherwise, values are mean antibody levels (SD) reported as arbitrary units per milliliter, except for anti-rubella virus, which is reported as international units per milliliter.