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Research Article | Host-Microbe Biology

Latent Membrane Protein 1 Is a Novel Determinant of Epstein-Barr Virus Genome Persistence and Reactivation

Elizabeth A. Caves, Rachel M. Butch, Sarah A. Cook, Laura R. Wasil, Chen Chen, Yuanpu Peter Di, Nara Lee, Kathy H. Y. Shair
Michael J. Imperiale, Editor
Elizabeth A. Caves
Cancer Virology Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
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Rachel M. Butch
Cancer Virology Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
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Sarah A. Cook
Cancer Virology Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
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Laura R. Wasil
Cancer Virology Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USADepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Chen Chen
Cancer Virology Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USADepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Yuanpu Peter Di
Cancer Virology Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USADepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Nara Lee
Cancer Virology Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USADepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Kathy H. Y. Shair
Cancer Virology Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USADepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Michael J. Imperiale
University of Michigan—Ann Arbor
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Clare E. Sample
Penn State University College of Medicine
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Shannon Kenney
University of Wisconsin–Madison
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DOI: 10.1128/mSphereDirect.00453-17
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Article Information

DOI 
https://doi.org/10.1128/mSphereDirect.00453-17
PubMed 
29134204

Published By 
American Society for Microbiology Journals
History 
  • Received October 2, 2017
  • Accepted October 8, 2017
  • Published online November 8, 2017.

Copyright & Usage 
Copyright © 2017 Caves et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Michael J. Imperiale, Editor, University of Michigan—Ann Arbor
  • Clare E. Sample, Solicited external reviewer, Penn State University College of Medicine
  • Shannon Kenney, Solicited external reviewer, University of Wisconsin–Madison

Author Information

  1. Elizabeth A. Cavesa,
  2. Rachel M. Butcha,
  3. Sarah A. Cooka,
  4. Laura R. Wasilab*,
  5. Chen Chenac,
  6. Yuanpu Peter Diac,
  7. Nara Leeab and
  8. Kathy H. Y. Shairab
  1. aCancer Virology Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
  2. bDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  3. cDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
      1. Address correspondence to Kathy H. Y. Shair, kas361{at}pitt.edu.
      1. E.A.C., R.M.B., and S.A.C. contributed equally to this work.

      • ↵* Present address: Laura R. Wasil, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.

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      Latent Membrane Protein 1 Is a Novel Determinant of Epstein-Barr Virus Genome Persistence and Reactivation
      Elizabeth A. Caves, Rachel M. Butch, Sarah A. Cook, Laura R. Wasil, Chen Chen, Yuanpu Peter Di, Nara Lee, Kathy H. Y. Shair
      mSphere Nov 2017, 2 (6) e00453-17; DOI: 10.1128/mSphereDirect.00453-17

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      Latent Membrane Protein 1 Is a Novel Determinant of Epstein-Barr Virus Genome Persistence and Reactivation
      Elizabeth A. Caves, Rachel M. Butch, Sarah A. Cook, Laura R. Wasil, Chen Chen, Yuanpu Peter Di, Nara Lee, Kathy H. Y. Shair
      mSphere Nov 2017, 2 (6) e00453-17; DOI: 10.1128/mSphereDirect.00453-17
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        • ABSTRACT
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      KEYWORDS

      Epstein-Barr virus
      gammaherpesvirus
      pathogenesis

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