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  • High Salt Cross-Protects Escherichia coli from Antibiotic Treatment through Increasing Efflux Pump Expression
  • Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009
  • Single-Cell Analysis Reveals Distinct Gene Expression and Heterogeneity in Male and Female Plasmodium falciparum Gametocytes
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Latest Articles

  • Impact of Long-Term Erythromycin Therapy on the Oropharyngeal Microbiome and Resistance Gene Reservoir in Non-Cystic Fibrosis Bronchiectasis
    Research Article | Host-Microbe Biology
    Impact of Long-Term Erythromycin Therapy on the Oropharyngeal Microbiome and Resistance Gene Reservoir in Non-Cystic Fibrosis Bronchiectasis

    Recent demonstrations that long-term macrolide therapy can prevent exacerbations in chronic airways diseases have led to a dramatic increase in their use. However, little is known about the wider, potentially adverse impacts of these treatments. Substantial disruption of the upper airway commensal microbiota might reduce its contribution to host defense and local immune regulation, while increases in macrolide resistance carriage would...

    Jocelyn M. Choo, Guy C. J. Abell, Rachel Thomson, Lucy Morgan, Grant Waterer, David L. Gordon, Steven L. Taylor, Lex E. X. Leong, Steve L. Wesselingh, Lucy D. Burr, Geraint B. Rogers
    18 Apr 2018
  • Malaria in Farmed Ungulates: an Exciting New System for Comparative Parasitology
    Editor's Pick Commentary | Host-Microbe Biology
    Malaria in Farmed Ungulates: an Exciting New System for Comparative Parasitology

    A wide array of vertebrates can serve as the intermediate hosts to malaria parasites (Apicomplexa: Haemosporida), such as birds, lizards, and several groups of mammals, including primates, bats, rodents, and ungulates. The latter group of hosts has not been intensively studied since early descriptions of a small set of taxa were published, but new reports of these parasites in both expected and new hosts have recently been published....

    Susan L. Perkins
    18 Apr 2018
  • Molecular Preadaptation to Antimony Resistance in <span class="named-content genus-species" id="named-content-1">Leishmania donovani</span> on the Indian Subcontinent
    Research Article | Molecular Biology and Physiology
    Molecular Preadaptation to Antimony Resistance in Leishmania donovani on the Indian Subcontinent

    The “antibiotic resistance crisis” is a major challenge for scientists and medical professionals. This steady rise in drug-resistant pathogens also extends to parasitic diseases, with antimony being the first anti-Leishmania drug that fell in the Indian subcontinent (ISC). Leishmaniasis is a major but neglected infectious disease with limited therapeutic options. Therefore, understanding how parasites became resistant to...

    F. Dumetz, B. Cuypers, H. Imamura, D. Zander, E. D’Haenens, I. Maes, M. A. Domagalska, J. Clos, J.-C. Dujardin, G. De Muylder
    18 Apr 2018
  • <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span><em> gshA</em> Mutant Is Defective in Biofilm Formation, Swarming, and Pyocyanin Production
    Research Article | Molecular Biology and Physiology
    Pseudomonas aeruginosa gshA Mutant Is Defective in Biofilm Formation, Swarming, and Pyocyanin Production

    Pseudomonas aeruginosa is a ubiquitous bacterium that can cause severe opportunistic infections, including many hospital-acquired infections. It is also a major cause of infections in patients with cystic fibrosis. P. aeruginosa is intrinsically resistant to a number of drugs and is capable of...

    Tricia A. Van Laar, Saika Esani, Tyler J. Birges, Bethany Hazen, Jason M. Thomas, Mamta Rawat
    18 Apr 2018
  • Iron Acquisition and Siderophore Release by Carbapenem-Resistant Sequence Type 258 <em>Klebsiella pneumoniae</em>
    Research Article | Host-Microbe Biology
    Iron Acquisition and Siderophore Release by Carbapenem-Resistant Sequence Type 258 Klebsiella pneumoniae

    Carbapenem-resistant Enterobacteriaceae, including K. pneumoniae, are a major health care concern worldwide because they cause a wide range of infection and are resistant to all or nearly all antibiotics. To cause infection, these bacteria must acquire iron, and a major mechanism of acquiring iron is by secreting a molecule called enterobactin that strips...

    Victoria I. Holden, Meredith S. Wright, Sébastien Houle, Abigail Collingwood, Charles M. Dozois, Mark D. Adams, Michael A. Bachman
    18 Apr 2018
  • The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells
    Research Article | Therapeutics and Prevention
    The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells

    Despite the availability of effective vaccines and treatments, HBV remains a significant global health concern, with more than 240 million individuals chronically infected. Current treatments are highly effective at controlling viral replication and disease progression but rarely cure infections. Therefore, much emphasis is being placed on finding therapeutics with new drug targets, such as viral gene expression, covalently closed...

    Andrew D. Huber, Jennifer J. Wolf, Dandan Liu, Anna T. Gres, Jing Tang, Kelsey N. Boschert, Maritza N. Puray-Chavez, Dallas L. Pineda, Thomas G. Laughlin, Emily M. Coonrod, Qiongying Yang, Juan Ji, Karen A. Kirby, Zhengqiang Wang, Stefan G. Sarafianos
    18 Apr 2018
  • Influential Parameters for the Analysis of Intracellular Parasite Metabolomics
    Research Article | Host-Microbe Biology
    Influential Parameters for the Analysis of Intracellular Parasite Metabolomics

    Molecular characterization of pathogens such as the malaria parasite can lead to improved biological understanding and novel treatment strategies. However, the distinctive biology of the Plasmodium parasite, including its repetitive genome and the requirement for growth within a host cell, hinders progress toward these goals. Untargeted metabolomics is a promising approach to learn about pathogen biology. By measuring many...

    Maureen A. Carey, Vincent Covelli, Audrey Brown, Gregory L. Medlock, Mareike Haaren, Jessica G. Cooper, Jason A. Papin, Jennifer L. Guler
    18 Apr 2018
  • Transmembrane Domains of Highly Pathogenic Viral Fusion Proteins Exhibit Trimeric Association <em>In Vitro</em>
    Observation | Molecular Biology and Physiology
    Transmembrane Domains of Highly Pathogenic Viral Fusion Proteins Exhibit Trimeric Association In Vitro

    Many important human pathogens are enveloped viruses that utilize membrane-bound glycoproteins to mediate viral entry. Factors that contribute to the stability of these glycoproteins have been identified in the ectodomain of several viral fusion proteins, including residues within the soluble ectodomain. Although it is often thought to simply act as an anchor, the transmembrane domain of viral fusion proteins has been implicated in...

    Stacy R. Webb, Stacy E. Smith, Michael G. Fried, Rebecca Ellis Dutch
    18 Apr 2018
  • Evolutionary Plasticity of AmrZ Regulation in <em>Pseudomonas</em>
    Research Article | Ecological and Evolutionary Science
    Evolutionary Plasticity of AmrZ Regulation in Pseudomonas

    Microbes often display finely tuned patterns of gene regulation across different environments, with major regulatory changes controlled by a small group of “master” regulators within each cell. AmrZ is a master regulator of gene expression across pseudomonads and can be either a positive or negative regulator for a variety of pathways depending on the strain and genomic context. Here, we demonstrate that the phenotypic outcomes of...

    David A. Baltrus, Kevin Dougherty, Beatriz Diaz, Rachel Murillo
    18 Apr 2018
  • Natural History of <em>Plasmodium odocoilei</em> Malaria Infection in Farmed White-Tailed Deer
    Editor's Pick Research Article | Clinical Science and Epidemiology
    Natural History of Plasmodium odocoilei Malaria Infection in Farmed White-Tailed Deer

    Malaria parasites of the genus Plasmodium are known to infect a variety of vertebrate hosts, including ungulates (hoofed mammals). A recent study found that up to a quarter of white-tailed deer (Odocoileus virginianus) in North America are infected with the parasite Plasmodium odocoilei. In...

    Ann M. Guggisberg, Katherine A. Sayler, Samantha M. Wisely, Audrey R. Odom John
    18 Apr 2018
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